Accutane down regulates androgen receptors

[ShredPill]

“The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein)”

Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. - PubMed - NCBI

In the study they look at androgen receptor in the skin, but they didnt biopsy anywhere else, so theres no reason to think that this isnt a system wide side effect. Rip if you took it in puberty, you would have grown a browridge and jaw

 

[AbandonShip]

Took it during puberty but still have good browridge and jaw.
The dosage was really mild and i relapsed but i didn't take it again. Acne are almost gone now

 

[ShredPill]

Took it during puberty but still have good browridge and jaw.
The dosage was really mild and i relapsed but i didn't take it again. Acne are almost gone now

Probably because you relapsed, meant that your body was able to recover

 

[AbandonShip]

Probably because you relapsed, meant that your body was able to recover

My dosage was really low. Like 20 mg/ day for one month and 10 mg/ day for another month.
Cumulative dose of 900 mg ( 15mg/ kg) which is considered a very low dose.

 

[Deleted member 773]

Min does the same thing

 

[ShredPill]

Min does the same thing

Yeah ive heard it may effect AR gene expression, but i dont think its as significant an effect. I took heavy doses daily for a couple months 2 years ago.

 

[Deleted member 773]

Yeah ive heard it may effect AR gene expression, but i dont think its as significant an effect. I took heavy doses daily for a couple months 2 years ago.

My dick hasnt been the same since I took it

 

[ShredPill]

My dick hasnt been the same since I took it

Seriously? That fucking sucks man. Does it not work at all? I noticed effects while on accutane but they passed after about year. I was certain at the time i was gonna have to start taking 300mgs of test to feel normal. Thankfully im pretty much back to normal, still mentally my libido isnt quite the same

 

[AbandonShip]

Seriously? That fucking sucks man. Does it not work at all? I noticed effects while on accutane but they passed after about year. I was certain at the time i was gonna have to start taking 300mgs of test to feel normal. Thankfully im pretty much back to normal, still mentally my libido isnt quite the same

What was your dosage? Please be precise

 

[ShredPill]

What was your dosage? Please be precise

I believe i started on a lower dose and worked my way up to 70mg, cant remember for how long tho. A few months

 

[balding17yomanletcel]

Accurane makes people manlet

 

[betamanlet]

Accurane makes people manlet

Can confirm.

 

[AbandonShip]

Accurane makes people manlet

Big if true

 

[Deleted member 773]

Seriously? That fucking sucks man. Does it not work at all? I noticed effects while on accutane but they passed after about year. I was certain at the time i was gonna have to start taking 300mgs of test to feel normal. Thankfully im pretty much back to normal, still mentally my libido isnt quite the same

IT works but it rarely gets all the way hard. Shit is getting better though I think. I'm 5 months off the drug.

 

[ShredPill]

IT works but it rarely gets all the way hard. Shit is getting better though I think. I'm 5 months off the drug.

Thats good man. Theres a few things that help eq regardless of any drugs/medications. Like improving cardio, going for a run daily, l arginine and other NO boosters.

 

[Titbot]

Cope it only affects the skin androgens not your muscles or bones

 

[Deleted member 2095]

Cope it only affects the skin androgens not your muscles or bones

Source

 

[Noodlewhore]

I took accutane 4 times.....from 15yo to 19yo to doses up to 100mg

I suffered to crazy bad cystic acne, and I look like a beta cuck

 

[ShredPill]

I took accutane 4 times.....from 15yo to 19yo to doses up to 100mg

I suffered to crazy bad cystic acne, and I look like a beta cuck

Im sorry my dude

 

[Deleted member 2095]

I took accutane 4 times.....from 15yo to 19yo to doses up to 100mg

I suffered to crazy bad cystic acne, and I look like a beta cuck

Pics

 

[her]

Accurane makes people manlet

how?

 

[ShredPill]

how?

Tanks your igf 1. Which is a killer if you’re in puberty

 

[her]

Tanks your igf 1. Which is a killer if you’re in puberty

it's over, i knew it, i took at 15 (which is when most people have the biggest growth spurt), and i never had a growth spurt in my life

is there anything i can do? i'm 16 now, turning 17 in february

 

[balding17yomanletcel]

it's over, i knew it, i took at 15 (which is when most people have the biggest growth spurt), and i never had a growth spurt in my life

is there anything i can do? i'm 16 now, turning 17 in february

Its over just kill yourself if you are 176cm and below bro

 

[ShredPill]

it's over, i knew it, i took at 15 (which is when most people have the biggest growth spurt), and i never had a growth spurt in my life

is there anything i can do? i'm 16 now, turning 17 in february

Theres plenty you can do. Mk677, 25mg every night, 200mcg of Huperzine a 3x a day. Gives you almost double your natural igf 1 as a gh bleed throughout your day. Can give a more in depth later if you want