gymislife
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After years of mild-moderate acne and trying all kinds of topicals - tretinoin, benzoyl peroxide, adapalene, salicylic acid, topical antibiotics and still getting breakouts + having an oily skin, I plan on taking 20 mg every 4 days in conjunction with retin-a.
My regime will be something like: Accutane20mg - rest day - Tretinoin 0.025% - rest - Accutane20mg - rest - Tretinoin 0.025% - rest, etc.
Using Accutane that way will result in getting in 5 mg daily, which is pretty effective for milder cases of acne (with very low chance of any sides):
If we look at this study where participants took 20 mg EOD, the risk of side effects was pretty low, the most common side effect was dry lips, which could be reduced with lip balm (and I'm even going to take a smaller dosage than that):
You can also look at this study and see how the group with lower dosage had much lesser sides than the group with conventional dosage while still getting in significant results in 87% of participants:
The reason why I'm going to take Tret and Accutane together is because IMO Tret does a better job for treating post inflammatory erythema and will lead to better results while using such small dosage of Accutane. Here's a study in which they gave patients combination therapy of Accutane + Tretinoin:
Also props to @Ringtaker for his amazing thread, make sure to check it out:
My regime will be something like: Accutane20mg - rest day - Tretinoin 0.025% - rest - Accutane20mg - rest - Tretinoin 0.025% - rest, etc.
Using Accutane that way will result in getting in 5 mg daily, which is pretty effective for milder cases of acne (with very low chance of any sides):
Isotretinoin 5 mg daily for low-grade adult acne vulgaris--a placebo-controlled, randomized double-blind study - PubMed
Isotretinoin 5 mg/day is effective in reducing the number of acne lesions, and improving patients dermatologic quality of life, with minimal adverse effects.
pubmed.ncbi.nlm.nih.gov
If we look at this study where participants took 20 mg EOD, the risk of side effects was pretty low, the most common side effect was dry lips, which could be reduced with lip balm (and I'm even going to take a smaller dosage than that):
Efficacy of fixed low-dose isotretinoin (20 mg, alternate days) with topical clindamycin gel in moderately severe acne vulgaris - PubMed
Six months of treatment with fixed-dose, alternate-day isotretinoin (20 mg) plus topical 1%clindamycin gel was found to be effective in the treatment of moderate acne in adult patients, with a low incidence of side-effects.
pubmed.ncbi.nlm.nih.gov
You can also look at this study and see how the group with lower dosage had much lesser sides than the group with conventional dosage while still getting in significant results in 87% of participants:
Comparing the Efficacy of Low Dose and Conventional Dose of Oral Isotretinoin in Treatment of Moderate and Severe Acne Vulgaris
This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne.This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The ...
www.ncbi.nlm.nih.gov
The reason why I'm going to take Tret and Accutane together is because IMO Tret does a better job for treating post inflammatory erythema and will lead to better results while using such small dosage of Accutane. Here's a study in which they gave patients combination therapy of Accutane + Tretinoin:
Low dose isotretinoin combined with tretinoin is effective to correct abnormalities of acne - PubMed
Because of the efficacy and cost-benefit relationship of isotretinoin in the treatment of acne compared to other therapeutic approaches, further use low dose isotretinoin in the described settings seems to justified.
pubmed.ncbi.nlm.nih.gov
Also props to @Ringtaker for his amazing thread, make sure to check it out:
(GTFIH) People with shitty skin, it's time you learn the truth and stop wasting time. The be all end all skincare thread. PLUS a promising new drug.
Disclaimer: This is a long ass post but will be worth it if you are suffering with shit skin. First, let's start off with what we currently have to topically combat acne. Salicylic Acid Benzoyl Peroxide Azelaic Acid Retin A (Tretinoin) Differin (Adapalene) Don't be duped by the skin care...
looksmax.org