Gebirgscel
horsedickpilled
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TL; DR: Let us hope, boyos, for a cure for MPB without killing DHT and therefore the dick
Fevipripant is the stronger form of Setipripant
It is very expensive, though. If you have asthma you could get it from healthcare
What is Setipiprant?
Setipiprant is an oral drug that’s currently being tested for use as a hair loss treatment. It was initially developed as a treatment for allergic rhinitis, but recent hair loss-related discoveries have made it a better candidate for hair loss reversal.
How Does It Work?
In short, setipiprant is an antagonist of the prostaglandin D2 receptor 2 (DP2). This receptor is responsible for bonding with and responding to certain prostaglandins, particularly PGD2. This prostaglandin has been linked to various pathological responses, including those linked to allergies, asthma, and inflammation.
For Hair Loss
In 2012, researchers discovered a link between the PGD2 receptor and hair loss. More specifically, this receptor is seen at high levels in the scalps of men diagnosed with Androgenetic Alopecia (AGA).
AGA (Male-Pattern Baldness) is the most common cause of hair loss in men, though it’s also seen in women (Female Pattern Hair Loss). It’s believed to be caused by a sensitivity to DHT, which is an androgen hormone that attaches to the follicles and leads to inflammation and irritation.
If left untreated, this inflammation causes hair follicle miniaturization. This can then lead to balding. But, where exactly does DHT fit in?
It’s known that PGD2 is produced from PGD2 synthase, an enzyme. And PGD2 synthase levels are increased by — you guessed it! — DHT. With an increase in PGD2, the PGD2 receptor on the scalp is then triggered, which causes inflammation.
According to researchers, setipiprant steps in before PGD2 attaches to the receptors, and therefore prevents receptor activation and, as a result, hair loss.
With the discovery of the possible link to PGD2 receptors, the drug was acquired by Kythera, and trials began to test the effects of setipiprant on hair loss.
Setipiprant vs. Finasteride
There’s no doubt that setipiprant and finasteride have a similar end game, and that’s to prevent hair loss. But how different are their mechanisms, and which is better?
If you think of the hair loss process as a timeline, then finasteride interferes much sooner in the process. That is, it inhibits the expression of 5-alpha-reductase (5AR), which is responsible for the production of DHT. In this way, less androgen receptors are activated on the scalp and PGD2 production is slowed or even ceased.
Setipiprant, though, enables 5AR to create DHT, and the process continues until PGD2 comes into play. It is then that the drug interferes, preventing PGD2 receptors from being activating (which is, essentially, the final step).
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
en.wikipedia.org
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
Fevipripant is the stronger form of Setipripant
It is very expensive, though. If you have asthma you could get it from healthcare
What is Setipiprant?
Setipiprant is an oral drug that’s currently being tested for use as a hair loss treatment. It was initially developed as a treatment for allergic rhinitis, but recent hair loss-related discoveries have made it a better candidate for hair loss reversal.
How Does It Work?
In short, setipiprant is an antagonist of the prostaglandin D2 receptor 2 (DP2). This receptor is responsible for bonding with and responding to certain prostaglandins, particularly PGD2. This prostaglandin has been linked to various pathological responses, including those linked to allergies, asthma, and inflammation.
For Hair Loss
In 2012, researchers discovered a link between the PGD2 receptor and hair loss. More specifically, this receptor is seen at high levels in the scalps of men diagnosed with Androgenetic Alopecia (AGA).
AGA (Male-Pattern Baldness) is the most common cause of hair loss in men, though it’s also seen in women (Female Pattern Hair Loss). It’s believed to be caused by a sensitivity to DHT, which is an androgen hormone that attaches to the follicles and leads to inflammation and irritation.
If left untreated, this inflammation causes hair follicle miniaturization. This can then lead to balding. But, where exactly does DHT fit in?
It’s known that PGD2 is produced from PGD2 synthase, an enzyme. And PGD2 synthase levels are increased by — you guessed it! — DHT. With an increase in PGD2, the PGD2 receptor on the scalp is then triggered, which causes inflammation.
According to researchers, setipiprant steps in before PGD2 attaches to the receptors, and therefore prevents receptor activation and, as a result, hair loss.
With the discovery of the possible link to PGD2 receptors, the drug was acquired by Kythera, and trials began to test the effects of setipiprant on hair loss.
Setipiprant vs. Finasteride
There’s no doubt that setipiprant and finasteride have a similar end game, and that’s to prevent hair loss. But how different are their mechanisms, and which is better?
If you think of the hair loss process as a timeline, then finasteride interferes much sooner in the process. That is, it inhibits the expression of 5-alpha-reductase (5AR), which is responsible for the production of DHT. In this way, less androgen receptors are activated on the scalp and PGD2 production is slowed or even ceased.
Setipiprant, though, enables 5AR to create DHT, and the process continues until PGD2 comes into play. It is then that the drug interferes, preventing PGD2 receptors from being activating (which is, essentially, the final step).
Does Prostaglandin D2 hold the cure to male pattern baldness?
Lipids in the skin are the most diverse in the entire human body. Their bioactivity in health and disease is underexplored. Prostaglandin D2 has recently been identified as a factor which is elevated in the bald scalp of men with androgenetic alopecia ...
www.ncbi.nlm.nih.gov
Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model
Hair loss and hair growth is the subject of tremendous amount of research.This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow ...
www.ncbi.nlm.nih.gov
Prostaglandin DP2 receptor - Wikipedia
In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss - PubMed
Overall, ricinoleic acid, acteoside, amentoflavone, quercetin-3-O-rutinoside and hinokiflavone were predicted to be PTGDS inhibitors with good pharmacokinetic properties and minimal adverse skin reactions. These compounds have the highest potential for further in vitro and in vivo investigation...
www.ncbi.nlm.nih.gov
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D[2] synthase (PTGDS) is elevated at ...
www.ncbi.nlm.nih.gov
Does Prostaglandin D2 hold the cure to male pattern baldness?
Lipids in the skin are the most diverse in the entire human body. Their bioactivity in health and disease is underexplored. Prostaglandin D2 has recently been identified as a factor which is elevated in the bald scalp of men with androgenetic alopecia ...
www.ncbi.nlm.nih.gov
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