NickGurr
200 ng/dl HIGH T BEAST
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Nicotine binds to the Nicotinic Acetylcholine receptors, and acts as as an agonist and also binds to the Muscarinic Acetylcholine receptors, acting as a weak antagonist.
Most of the Nicotinic Acetycholine receptors are located presynaptically, which means they control the release of neurotransmitters, while less of them are located postsynaptically, reacting to the neurotransmitters received.
Nicotine affects both of these. The Nicotinic Acetylcholine presynaptic receptors regulate the release of Acetylcholine, Dopamine, Serotonin, Glutamate, GABA and Adrenaline. Stimulation of these by Nicotine causes an increased release of the previously mentioned neurotransmitters, as well as an increased secretion of Growth Hormone. It also causes an improvement in long-term memory.
Unfortunately, prolongue exposure to Nicotine causes an increase to tolerance to its effects. Over time, as each of the neurotransmitters will stop being affected by Nicotine, the first of which is GABA. GABA regulates the release of Dopamine, so the lowered level of GABA will cause even more Dopamine to be released by Nicotine.
This tolerance can possibly be reversed by a Nicotinic Acetylcholine receptor Positive Allosteric Modulator like PNU-120596 or AVL-3288.
The GABA levels are also lowered by Nicotine’s ability to release Beta-Endorphin, which binds to the Mu Opioid receptors, which causes pain reduction, sedation, nausea, euphoria, etc.
The agonism of the Nicotinic Acetycholine receptors also cause a two-fold increase of cAMP in the muscles, which increases muscle protein catabolism, which will increase muscle loss and has the role of using muscle as an energy source. This effect is antagonized by the release of Beta-Endorphin.
Nicotine’s weak antagonism of Muscarinic Acetylcholine receptors seem to have a slight synergistic effect with the Nicotinic Acetylcholine receptor agonism, with only a few possible side effects (Contraction of the soft muscles which causes a slight urinary retention, as well as a reduced instestinal motility which can cause nausea, reduced acid secretions in the stomach).
The overall effects of Nicotine seem to be able to improve symptoms of RLS and Parkinson’s, as well as Altzheimer’s and others, with few side effects.
Most of the Nicotinic Acetycholine receptors are located presynaptically, which means they control the release of neurotransmitters, while less of them are located postsynaptically, reacting to the neurotransmitters received.
Nicotine affects both of these. The Nicotinic Acetylcholine presynaptic receptors regulate the release of Acetylcholine, Dopamine, Serotonin, Glutamate, GABA and Adrenaline. Stimulation of these by Nicotine causes an increased release of the previously mentioned neurotransmitters, as well as an increased secretion of Growth Hormone. It also causes an improvement in long-term memory.
Unfortunately, prolongue exposure to Nicotine causes an increase to tolerance to its effects. Over time, as each of the neurotransmitters will stop being affected by Nicotine, the first of which is GABA. GABA regulates the release of Dopamine, so the lowered level of GABA will cause even more Dopamine to be released by Nicotine.
This tolerance can possibly be reversed by a Nicotinic Acetylcholine receptor Positive Allosteric Modulator like PNU-120596 or AVL-3288.
The GABA levels are also lowered by Nicotine’s ability to release Beta-Endorphin, which binds to the Mu Opioid receptors, which causes pain reduction, sedation, nausea, euphoria, etc.
The agonism of the Nicotinic Acetycholine receptors also cause a two-fold increase of cAMP in the muscles, which increases muscle protein catabolism, which will increase muscle loss and has the role of using muscle as an energy source. This effect is antagonized by the release of Beta-Endorphin.
Nicotine’s weak antagonism of Muscarinic Acetylcholine receptors seem to have a slight synergistic effect with the Nicotinic Acetylcholine receptor agonism, with only a few possible side effects (Contraction of the soft muscles which causes a slight urinary retention, as well as a reduced instestinal motility which can cause nausea, reduced acid secretions in the stomach).
The overall effects of Nicotine seem to be able to improve symptoms of RLS and Parkinson’s, as well as Altzheimer’s and others, with few side effects.