JustBeCurry
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Let me preface this by saying please do your own research before you take anything.
scroll down for tldr and the stack
Article on bodybuilding.com with all the information mentioned in this thread including studies:
Technical Stuff
A brief summary of what the HPTA is, how it works, and why you do not want to be shutting it down:
Endogenous testosterone production(testosterone made inside your body) is governed by the HPTA(Hypothalamus-Pituitary-Testes-Axis). The hypothalamus releases a hormone called GnRH(or LH-releasing hormone); the hypothalamus maintains homeostatic control so you do not want to be fucking up the hypothalamus or any related part of the HPTA. The GnRH then goes to the pituitary gland to produce two other hormones LH(Luteinizing Hormone) and FSH(Follicle-Stimulating Hormone), which then the two hormones go the testes, and finally, you get testosterone synthesis and sperm production. The HPTA and the GnRH, LH, and FSH produced from it regulates the amount of testosterone, androstenediol, and DHEA in your body. If your HPTA produces extra GnRH, LH, and FSH you also get all the anabolic things like testosterone, and that is exactly why you don't want to it to crash from early steroid use and/or shitty PCT.
Why do you get side effects from steroids and the key to fixing the HPTA:
Most people know the estrogen-related side effects of steroids and why you absolutely do not want them. There are actually two negative feedback loops controlling the HPTA, the estrogen negative feedback loop, and the lesser-known androgen negative feedback loop. When too much estrogen interacts with the estrogen receptors of the hypothalamus, there's a negative feedback loop where the gland thinks there must be too much testosterone too, causing loss of testosterone or even shutdown. The hypothalamus also has androgen receptors, when it senses that there is too many androgens it causes a decrease or shutdown in GnRH release. This is probably why your balls shrink on steroids and you lose sexual function.
Common PCT and its faults:
Normal PCT would be something like Clomid, an AI(Anastrolzole is the one we're going to be talking about), and HCG. Clomid is actually a very weak estrogen that blocks more powerful estrogens from merging with the hypothalamic estrogen receptors, this causes the hypothalamus to detect less estrogen and to increase GnRH release. Anastrozole is an aromatase enzyme inhibitor that decreases conversions of androgens into estrogens, which leads to a decrease in total circulatory estrogen and has some benefits of HPTA regeneration. HCG or Human Chorionic Gonadotropin in males has been shown to mimic LH, so it leads to the direct stimulation of the testes resulting in a minimal increase in sperm production and a significant increase in testicular testosterone production.
Addressing the androgen negative feedback loop:
Until pretty recently hypothalamus-specific androgen inhibition wasn't possible, there are some 'new' compounds that have been introduced.
3-OHAT: 6,17-dioxo-etiocholene-3-ol or 3-OHAT is a metabolite of a popular anti-aromatase supplement 4-androstene-36,17-trione(AT). 3-OHAT has a longer half-life than AT, and it is also a non-androgenic aromatase inhibitor(very important for the androgen negative feedback loop). 3-OHAT is a fast-acting long-term destroyer of the estrogen negative feedback loop, and consequently increases testosterone
ATD:3,17-dioxo-etiochol-1,4,6-triene or ATD is 2.8 times more powerful than AT and more powerful than 3-OHAT in a different way. In vitro studies have shown ATD to be a powerful androgen receptor blocker of the hypothalamus, but not of peripheral androgen receptors. Basically, this means it blocks the androgen negative feedback loop caused by the hypothalamus, so in turn GnRH release increases resulting in decreased estrogen production while increasing natural testosterone production. If the dosages of 3-OHAT and ATD are combined correctly there is an average increase in bioavailable testosterone of up to 400% and a direct decrease in estrogens of an average 50%, and this is proven by studies.
Real-world testing:
Eight human test subjects were used in a study on ATD and 3-OHAT, four were placebo base-line and the other four received a blend consisting of 3-OHAT and ATD.
Placebo Group:
No significant changes in total or free testosterone and estradiol(obvious)
Subject 1 (24yr old male:
Pre-testing-
Total T: 350ng/dl
Free T: 83.00pg/ml
Estradiol: 39pg/ml
14 Days-
Total T: 1803ng/dl
Free T: 522.90pg/ml
Estradiol:27pg/ml
42 Days-
Total T: 2895ng/dl
Free T: 839.20pg/ml
Estradiol: <20
Subject 2 (33yr old male):
Pre-testing-
Total T: 538ng/dl
Free T: 129.0pg/ml
Estradiol: 30pg/ml
14 Days-
Total T: 998ng/dl
Free T: 233.0pg/ml
Estradiol: 22pg/ml
42 Days-
Total T: 1416ng/dl
Free T: 421.3pg/ml
Estradiol: 22pg/ml
Subject 3 (25yr old male):
Pre-testing-
Total T: 555ng/dl
Free T: 104.00pg/ml
Estradiol: <20
14 Days-
Total T: 1624ng/dl
Free T: 405.7pg/ml
Estradiol: <20
42 Days-
Total T: 1837ng/dl
Free T: 405.7pg/ml
Estradiol: <20
Subject 4 (51yr old male):
Pre-testing-
Total T: 584ng/dl
Free T: 13.40ng/dl
Estradiol: 47pg/ml
14 Days-
Total T: 851ng/dl
Free T: 26.10ng/dl
Estradiol <20
42 Days-
Total T: 875ng/dl
Free T: 30.30ng/dl
Estradiol: <20
What does this mean for looksmax.me and roidcels:
So basically we need to take something with 3-OHAT and ATD to successfully prevent androgen and estrogen negative feedback loops. There used to exist products with actual 3-OHAT and ATD, but most of them have been recalled, as well as ATD being banned as a supplement. Unless if you have some contacts then getting real 3-OHAT and ATD is a no-go for most of us.
Actual important bit
The ultimate PCT:
Novedex XT, this is all you need. A previous version of this Novedex XT included real 3-OHAT and ATD, but since it's banning the formula has been updated. The new versions formula includes 3b-hydroxy-androsta-1,4,6-triene-17-one, 3b-hydroxy-androsta-4,6-diene-17-one, and androsta-3,5-diene-7,17-dione.
Novedex XT does not have any androgenic metabolites that could cause HPTA suppression. 3b-hydroxy-androsta-4,6-diene-17-one is the so called 'ATD imposter' due to its structure and mechanism of action and it is a steroidal aromatase inhibitor, permanently binding to the aromatase enzyme. 3,5-dien-7,17-dione is another potent aromatase inhibitor.
TLDR; Nolvadex XT is a PCT that will help restore HPTA function and does not have any suppression to it.
Thanks for reading if you read all this. TAG YOUR FRIENDS BRO
REMINDER: I'M NOT ADVOCATING YOU TRY THIS OR SHILLING FOR THIS PRODUCT, IT SEEMS PROMISING BUT I MYSELF HAVE NOT TRIED IT, BUT WILL IN THE FUTURE
@Lev Peshkov
@xefo69
@ItisOver
only people I know who to tag lmao
scroll down for tldr and the stack
Article on bodybuilding.com with all the information mentioned in this thread including studies:
HPTA Supraphysiological Overcompensation: The Holy Grail Of Optimized Natural Human Performance
The first and most important How-to answer in the optimization of human performance begins with HPTA Supraphysiological Overcompensation. Learn more...
www.bodybuilding.com
Technical Stuff
A brief summary of what the HPTA is, how it works, and why you do not want to be shutting it down:
Endogenous testosterone production(testosterone made inside your body) is governed by the HPTA(Hypothalamus-Pituitary-Testes-Axis). The hypothalamus releases a hormone called GnRH(or LH-releasing hormone); the hypothalamus maintains homeostatic control so you do not want to be fucking up the hypothalamus or any related part of the HPTA. The GnRH then goes to the pituitary gland to produce two other hormones LH(Luteinizing Hormone) and FSH(Follicle-Stimulating Hormone), which then the two hormones go the testes, and finally, you get testosterone synthesis and sperm production. The HPTA and the GnRH, LH, and FSH produced from it regulates the amount of testosterone, androstenediol, and DHEA in your body. If your HPTA produces extra GnRH, LH, and FSH you also get all the anabolic things like testosterone, and that is exactly why you don't want to it to crash from early steroid use and/or shitty PCT.
Why do you get side effects from steroids and the key to fixing the HPTA:
Most people know the estrogen-related side effects of steroids and why you absolutely do not want them. There are actually two negative feedback loops controlling the HPTA, the estrogen negative feedback loop, and the lesser-known androgen negative feedback loop. When too much estrogen interacts with the estrogen receptors of the hypothalamus, there's a negative feedback loop where the gland thinks there must be too much testosterone too, causing loss of testosterone or even shutdown. The hypothalamus also has androgen receptors, when it senses that there is too many androgens it causes a decrease or shutdown in GnRH release. This is probably why your balls shrink on steroids and you lose sexual function.
Common PCT and its faults:
Normal PCT would be something like Clomid, an AI(Anastrolzole is the one we're going to be talking about), and HCG. Clomid is actually a very weak estrogen that blocks more powerful estrogens from merging with the hypothalamic estrogen receptors, this causes the hypothalamus to detect less estrogen and to increase GnRH release. Anastrozole is an aromatase enzyme inhibitor that decreases conversions of androgens into estrogens, which leads to a decrease in total circulatory estrogen and has some benefits of HPTA regeneration. HCG or Human Chorionic Gonadotropin in males has been shown to mimic LH, so it leads to the direct stimulation of the testes resulting in a minimal increase in sperm production and a significant increase in testicular testosterone production.
Addressing the androgen negative feedback loop:
Until pretty recently hypothalamus-specific androgen inhibition wasn't possible, there are some 'new' compounds that have been introduced.
3-OHAT: 6,17-dioxo-etiocholene-3-ol or 3-OHAT is a metabolite of a popular anti-aromatase supplement 4-androstene-36,17-trione(AT). 3-OHAT has a longer half-life than AT, and it is also a non-androgenic aromatase inhibitor(very important for the androgen negative feedback loop). 3-OHAT is a fast-acting long-term destroyer of the estrogen negative feedback loop, and consequently increases testosterone
ATD:3,17-dioxo-etiochol-1,4,6-triene or ATD is 2.8 times more powerful than AT and more powerful than 3-OHAT in a different way. In vitro studies have shown ATD to be a powerful androgen receptor blocker of the hypothalamus, but not of peripheral androgen receptors. Basically, this means it blocks the androgen negative feedback loop caused by the hypothalamus, so in turn GnRH release increases resulting in decreased estrogen production while increasing natural testosterone production. If the dosages of 3-OHAT and ATD are combined correctly there is an average increase in bioavailable testosterone of up to 400% and a direct decrease in estrogens of an average 50%, and this is proven by studies.
Real-world testing:
Eight human test subjects were used in a study on ATD and 3-OHAT, four were placebo base-line and the other four received a blend consisting of 3-OHAT and ATD.
Placebo Group:
No significant changes in total or free testosterone and estradiol(obvious)
Subject 1 (24yr old male:
Pre-testing-
Total T: 350ng/dl
Free T: 83.00pg/ml
Estradiol: 39pg/ml
14 Days-
Total T: 1803ng/dl
Free T: 522.90pg/ml
Estradiol:27pg/ml
42 Days-
Total T: 2895ng/dl
Free T: 839.20pg/ml
Estradiol: <20
Subject 2 (33yr old male):
Pre-testing-
Total T: 538ng/dl
Free T: 129.0pg/ml
Estradiol: 30pg/ml
14 Days-
Total T: 998ng/dl
Free T: 233.0pg/ml
Estradiol: 22pg/ml
42 Days-
Total T: 1416ng/dl
Free T: 421.3pg/ml
Estradiol: 22pg/ml
Subject 3 (25yr old male):
Pre-testing-
Total T: 555ng/dl
Free T: 104.00pg/ml
Estradiol: <20
14 Days-
Total T: 1624ng/dl
Free T: 405.7pg/ml
Estradiol: <20
42 Days-
Total T: 1837ng/dl
Free T: 405.7pg/ml
Estradiol: <20
Subject 4 (51yr old male):
Pre-testing-
Total T: 584ng/dl
Free T: 13.40ng/dl
Estradiol: 47pg/ml
14 Days-
Total T: 851ng/dl
Free T: 26.10ng/dl
Estradiol <20
42 Days-
Total T: 875ng/dl
Free T: 30.30ng/dl
Estradiol: <20
What does this mean for looksmax.me and roidcels:
So basically we need to take something with 3-OHAT and ATD to successfully prevent androgen and estrogen negative feedback loops. There used to exist products with actual 3-OHAT and ATD, but most of them have been recalled, as well as ATD being banned as a supplement. Unless if you have some contacts then getting real 3-OHAT and ATD is a no-go for most of us.
Actual important bit
The ultimate PCT:
Novedex XT, this is all you need. A previous version of this Novedex XT included real 3-OHAT and ATD, but since it's banning the formula has been updated. The new versions formula includes 3b-hydroxy-androsta-1,4,6-triene-17-one, 3b-hydroxy-androsta-4,6-diene-17-one, and androsta-3,5-diene-7,17-dione.
Novedex XT does not have any androgenic metabolites that could cause HPTA suppression. 3b-hydroxy-androsta-4,6-diene-17-one is the so called 'ATD imposter' due to its structure and mechanism of action and it is a steroidal aromatase inhibitor, permanently binding to the aromatase enzyme. 3,5-dien-7,17-dione is another potent aromatase inhibitor.
TLDR; Nolvadex XT is a PCT that will help restore HPTA function and does not have any suppression to it.
Thanks for reading if you read all this. TAG YOUR FRIENDS BRO
REMINDER: I'M NOT ADVOCATING YOU TRY THIS OR SHILLING FOR THIS PRODUCT, IT SEEMS PROMISING BUT I MYSELF HAVE NOT TRIED IT, BUT WILL IN THE FUTURE
@Lev Peshkov
@xefo69
@ItisOver
only people I know who to tag lmao