Im taking seggligine(I think its gaba t its similair to nardil) and sometimes lyrica but lyrica at 200-300mg made me walk funny. I feel like you lose iq when your on it. It has an alcohol type effect.
check selleckchem.com
yeah it works by removing old traumatic memories and the anxiety associated with them. It sounds like a miracle and there is a fair amount of testimonies on this.
whats your current stack for mentalceldom and has it helped?
1.25/2.5mg subliminally seggligine every other day (3x a week).
️Bromantane > Lyrica
my mother looked at one of my packages and knows i ordered drugs. I wanted to get bromatane aswell from swisschems, but that shit is more for careermaxxing isnt it?
raypeater I see
I plan to keep drugs at Wolt's bag
Nothin
have you been using long term and it helped both socially and career wise(concentration)
which one does that? you guys mentioned a few in the post.
which one does that? you guys mentioned a few in the post.
Do you mean vorinostat for healing brain and removing traumatic memory anxiety?
My brain cant function since 2014. and my dr only recommended sleep, vegies and sports
Now I need to deliver this without my family finding out
how much vorinostat should I order in your opinion? If you claim the standard dose is 50mg and most people need max 5 sessions. then 1g should be more than ideal?
I feel that would be a hard site to order from, you have to LARP as a research institute. SelleckChem seems more lenient in that regard.
Wym they don't check prescriptions? Like u can just go to a pharma store and buy it? If so it's lifefuel (I'm Lithuanian)
@Tai Lung got accutane without prescription and just said he left it at home jfl
Btw bro do u think Selegiline + Lyrica is a good combo? I know nardil + Lyrica is god tier but it's hard to source nardil, I'm hoping selegiline can at least be partially as good
That's the stack I've been running, I got it from bgpharma, segligine Is a god substance for general life but I don't really like lyrica it makes you low inhib but I feel like I lose iq and just reduces anxiety but ultimately you are still an autist.
How much selegiline are you dosing?
2.5 subliginally every other day. oral is cope its 4x less effective.
My personal experience and the experience of many others would suggest that it does help significantly with anxiety-related conditions. There are anecdotals posted here by users like our admin @Alexanderr and on other sites stating that it was life-changing. Vorinostat is much more nuanced than just the fact that it abolishes fear. The fact that it alters gene expression through the targeting of specific HDAC classes is where the novel aspect of it comes from. You’re obviously not going to find much evidence related to studies lol, no human blind study related to mental benefits has been conducted.
Nardil’s inhibition of GABA-transaminase is a significant distinction. Arguably more anxiolytic than benzos without the risk of building tolerance or going through withdrawals due to the lack of downregulation. Both are just as easy to procure if you live in the states.
Everyone who says this has never taken prescription Lyrica and only the curry garbage found on the clearnet. Anyone getting it from a pharmacy knows the difference. I always get an anxiolytic effect from it every single time I take it even after consistently taking it for 2.5 years and zero cognitive impairment cuz I don’t abuse it.
It’s nothing compared to Vorinostat and Nardil/Parnate but not useless.
There is way more research on Cerebrolysin and more of a proven track record. Also P21 is very expensive and harder to source.
Probably placebo. I and @androgenic have used Vorinostat extensively & have discussed it at length. We both haven't noticed much at all. My verbal fluency is way way up though and I've noticed it helps immensely with language learning. I don't see it doing absolutely anything with infrequent dosing. I was using it daily for a while but I stopped because it wasn't doing anything for my OCD which I honestly thought it would have abolished when utilized in conjunction with ERP.
Yes I've read the entire thread on longecity. Results seem meh.
Humans sure. I've read multiple rat studies and a fair few speculative articles in fear extinction.
Anything GABA related can never be sustained. Everyone who has ever tried to manipulate anything regarding the GABA system eventually comes to the conclusion that a poop-out is a given. It's the one system that will literally do everything to maintain homeostasis. Baclofen is actually an outlier in this regard because GABAb receptor density bounces back very quickly and seems to be quite formidable when agonized for long periods of time. I've used baclofen pretty successfully and sustained it for a while, I only quit because the next-day sedation was too overwhelming. It's provided the most anxiolysis out of any GABAergic I've used and it was intensely antidepressant.
The fact that you're still using this argument is laughable. I've used Pfizer pregab and I've used curry slop, absolutely no tangible difference, in fact, I had 1kg of pure Pregabalin that tested at 99% purity at one point. Again, no difference.
Nah it's dogshit. Poops out like everything dopaminergic.
P21 is literally the peptide in Cerebrolysin that is primarily responsible for the increase in BDNF expression. It's just synthetic and the fact that it's isolated means you're not running the risk of hairloss and what not when using Cerebrolysin.
I thought @androgenic had a good response? He made an entire thread on it. Didn't know you took it yourself, you didn't make that clear in your post.
You're grossly uninformed on this but that's ok. Nardil's effect on GABA-tramsaminase works independently from the synthesis of GABA as the increase in GABA levels is based on levels of Vitamin B6. This works completely different from typical GABA receptor agonists since they decrease GABA by increasing receptor sensitivity. Downregulation occurs with reoccurring use of said agent and you’re left with less GABA due to the Glutamatergic system overcompensating as a result. That is very different from Nardil's MoA which works to increase GABA by attempting to balance the GABAergic-Glutamatergic system.
Phenelzine's anxiolytic effect does lessen, but for the vast majority of users the effect sustains. If corrective measures are taken, the GABAergic effect can be increased.
Yes, I have also taken Pfizer Pregab from the clearnet and it significantly different than what it is from the pharmacy. No tangible difference for you, but for every responder there is.
Not sustainable yet I continue to take it daily with zero issues. Please cite the hundreds of reports for me, you literally just say shit lol. Gabapentin poops out violently, Lyrica is way more consistent. The current brand I'm taking is not at all sedating and actually gives me energy. Your argument does not make sense at all pharmacologically.
Learn to manipulate the dopaminergic system better.
P21 is a man-made counterpart of CNTF. Like you said its synthetic, therefore not actually found in Cerebro.
I literally haven't tried sourcing it myself lol
I did the same. Only taking Lyrica which I have zero downsides from.
Yeah he thought he did at the start but has since changed his mind.I thought @@androgenic had a good response? He made an entire thread on it. Didn't know you took it yourself, you didn't make that clear in your post.
Huh I've posted in this thread before. Bought it ages ago
I was looking into it a while ago. Just look it up. It isn't like Crebinostat tier but the BBB penetration is way higher than Vorinostat
What are you on about? I didn't even mention GABA-T. I just said that EVERYTHING that touches GABA in any way imaginble will cause adaptive changes and inevitable downregulation/desenistization. GABAergics are gross and should be avoided entirely if you like your sanity. Pregabalin clears all of them.
There are structural differences between GABAb and GABAa. BPC157, for example, has been shown to reverse tolerance on GABAb but does nothing for GABAa. Tolerance to baclofen is astoundingly low and I haven't seen many anecdotes of people having to increase dosage over time. But yeah it's just like anything GABA-related.
Why are you trying to school me on something I'm quite understanding of?
Can you give me an example? You can only augment so many times until your augmentation needs augmentation. Psych meds are a complete fucking joke.
Each to their own I suppose. I just don't like pregabalin ig.
Brother I've been doing this for years. Ironically normalising dopaminergic transmission with aripiprazole gave me better results than using literal meth tbh.
I concede
Fair enough. If you can sustain it props to you. I can't ejaculate or work out on pregab so I had to drop it. Plus I've got way to much of an addictive personaility and it made me sleep for half the day.
I found some on madeinchina and it's from the source I usually buy my raws from. If I get a batch I can send it to Janoshik for HPLC and I'd definitley be down to send you as much as you need for free. Lmk
pubmed.ncbi.nlm.nih.gov
People tolerate moais differently. Some hate Nardil because it's overly sedating and others don't like parnate because it's overly activating. The moa is obviously the exact same but there are slight differences obviously.
What about selegiline?@Cope I don't know if you've seen these studies but they're incredibly interesting, especially for those using HDAC inhibitors.
Basically If I'm not retarded they're suggesting that an increase in acetylation of the histone H3 protein is present in ethanol withdrawing rats. The acetylation is responsible for the adaptive changes to the both GABAa and GABAb receptor structure supposedly, only in some subunits though. This is why I want to source panobinostat.
The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam - PubMed
A novel gastric pentadecapeptide BPC 157 with different beneficial activities and anticonvulsant effect interacting with GABAergic system could improve diazepam efficacy coadministered (10 microg/kg, 10 ng/kg i.p.) with diazepam (5.0 mg/kg i.p.) twice daily for 10 days, since diazepam chronic...
Here's a good thread on Longecity:
BPC-157:fixes neurotransmitter systems - experiences? - Mental Health
BPC-157:fixes neurotransmitter systems - experiences? - posted in Mental Health: i found this on reddit and am curious to know if anyone has had any good experiences repairing their brains with BPC-157: https://www.reddit.c...as_a_nootropic/ from the link above: BPC-157 reduces tolerance...www.longecity.org
People tolerate moais differently. Some hate Nardil because it's overly sedating and others don't like parnate because it's overly activating. The moa is obviously the exact same but there are slight differences obviously.
I don't think parnate is better but it's definitely more easily avaliable (outside of the USA) and phenelzine is barely produced in comparison to tranylcypromine. In Australia for example Phenelzine literally just got reintroduced after years of no longer being domestically produced/prescribed.
selegiline is pretty good. It metabolises into levoamphetamine though iirc.
So what do u think its the best for anxiety so far
I did, that's why I asked. All I could find was the difference in bioavailability, in which Vorinostat was higher:
Nardil's mechanism of action is different from typical GABAergics and just because it's a "GABA-T inhibitor" that in no way means that it operates like conventional inhibitors of GABA-tramsaminase. It's based on levels of pyroxidine (B6) and phenethylidenehydrazine (PEH). It does not cause an overcompensation of glutamate transmission. Nardil creates a balance, and when there's a balance receptors aren’t overwhelmed or downregulated.
I know, I previously just said GABA-B receptor agonists are more forgiving for this reason. I already stated Baclofen's half-life is short which is why tolerance is low. The reverse tolerance is negligible because something like the notorious GABA-B agent Phenibut causes rapid tolerance and withdrawal issues.
Typically the best augments are actually supplements. Vitamin B6 (pyroxidine version) augments the GABAergic effect since GABA-transaminase is dependent upon it. L-Tryptophan works really to induce a calming aspect of Nardil since it competes with other trace amine neuromodulators like phenethylamine, which causes the amphetamine like effect you can get from it.
Abilify, really? That med made feel so uncomfortable, I hate ATPs.
lol Forreal? That would be a huge hook-up my dude, I'd definitely appreciate that if you could.
Good find. It's interesting because I did notice Vorinostat helped somewhat when I was going thru benzo withdrawals. There appears to be a strong correlation between HDACis and the GABA-A subunits.
Okay. Yeah I had no clue about the b6 thing.
This is something that interests me. Pharmacologically there isn't any difference between Baclofen and Phenibut in terms of it's interaction and affinity towards GABAb. Phenibut's oral bioavailability is what necessitates such high dosages in comparison to Baclofen, and I've used Baclofen in conjunction with Pregabalin and the effect did not emulate that of Phenibut's whatsoever. Pregabalin's primary moa is through VGCC channel inhibiton which essentially just blocks the release of acetylcholine, dopamine, serotonin and glutamate.
You make it sound amazing tbh. I've spent a lot of time on the MOAi reddit and a lot of people there seem to have finally reached serenity so to speak. I think the best augmentation would just be phenidates and or/amphetamines. Lamotrigine seems to be one of the best psych meds but it literally gave me acne and my hair was falling out even on minoxidil and finasteride.
This one interested me for a while. Doesn't it just antagonise autoreceptors which leads to an increase in Dopamine? I feel like that effect would wane over time because other autoreceptors (D3) would just detect an influx in Dopamine and shut everything down.
Yeah It was a weird experience to say the least. It gave me a disgusting libido, never felt more consumed by sexual thoughts ever. Dropped it because it gave me akathesia. Was decent up until that point though, was very antidepressant (I don't have depression but I have really shocking OCD and it did nothing for that)
Yeah with Janoshik I don't feel scared to purchase raws from china. I just send a batch to Janoshik and they almost always come back really high quality. I've gotten Lamotrigine raws, Clomipramine raws and Vorinostat as well.
Discord is nick301775.
Ah probably not. I actually learnt a lot from you back in the day (it's Dyorotic2 ahah)
HDACi are actually incredibly fasinating. They're actually being studied at the moment for their potential ability to essentially rip the latent HIV cells out of the "reservoirs" and in conjunction with retroviral therapy destroy the replication forever. Panobinostat was the most effective out of all the hdaci.
Panobinostat penetrates the blood–brain barrier and achieves effective brain concentrations in a murine model
