BrahminBoss
Brownmaxxing
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BOTB has hylauronic acid as the perfect skin barrier solution for tretinoin (which damges it if overused) and for increasing the water retaining properties of the NMF (Natural moisturizing factor) present in the epidermis. Turns out urea is as good as hylauronic acid at these jobs and also provides some additional benefits:
Urea is a hygroscopic molecule (capable of absorbing water) present in the epidermis as a component of the natural moisturizing factor (NMF) and is essential for the adequate hydration and integrity of the stratum corneum. Urea improves skin barrier function including antimicrobial defense by regulating gene expression in keratinocytes relevant for their differentiation and antimicrobial peptide production
Furthermore, urea can increase skin penetration and optimize the action of topical drugs. Urea-based products are well tolerated; their side effects are mild and are more frequent at high concentration.
A reduction in the hygroscopic capacity of the skin can increase transepidermal water loss (TEWL), deregulate epidermal proliferation and inhibit skin desquamation, inducing hyperkeratosis and pruritus [1].
In Asia, Africa and Europe, the therapeutic use of urine (urotherapy) has been documented for centuries. One of the first uses of urea in modern medicine was the topical treatment of wounds due to its proteolytic and antibacterial properties [2]. Currently, urea is widely used in dermatology. It is prescribed for the treatment of diverse dermatoses presenting with scaly and dry skin such as atopic dermatitis, ichthyosis, seborrheic dermatitis and psoriasis, among others
Urea:
1. Increases moisturization of the stratum corneum:
Urea reduces TEWL and increases water retention and the resistance of the stratum corneum against osmotic stress. Furthermore, urea can act as an endogenous humectant replacing water in low humidity conditions
2.Improves skin's barrier function and antimicrobial defense
3. Regulates epidermial proliferation:
Urea is a highly active molecule and an important regulator of epidermal structure and function. Urea plays a fundamental role in controlling keratinocyte proliferation: it decreases DNA synthesis in basal cells and prolongs the generation time of post-mitosis epidermal cells. Urea induces a reduction in cellularity, resulting in epidermal thinning
4. Increases drug penetration:
Urea can facilitate the transport of molecules such as antifungals, corticosteroids and hormones through the skin and nails. This effect seems to be secondary to increased water absorption by keratinocytes in the presence of urea and to its keratolytic action
Products with low or medium concentration (2%–20%) of urea may be indicated for routine skin care in individuals without skin disorders . Urea can decrease TEWL , increase the water content of the stratum corneum, optimize the skin barrier function and upregulate antimicrobial peptides in the skin
Urea is a hygroscopic molecule (capable of absorbing water) present in the epidermis as a component of the natural moisturizing factor (NMF) and is essential for the adequate hydration and integrity of the stratum corneum. Urea improves skin barrier function including antimicrobial defense by regulating gene expression in keratinocytes relevant for their differentiation and antimicrobial peptide production
Furthermore, urea can increase skin penetration and optimize the action of topical drugs. Urea-based products are well tolerated; their side effects are mild and are more frequent at high concentration.
A reduction in the hygroscopic capacity of the skin can increase transepidermal water loss (TEWL), deregulate epidermal proliferation and inhibit skin desquamation, inducing hyperkeratosis and pruritus [1].
In Asia, Africa and Europe, the therapeutic use of urine (urotherapy) has been documented for centuries. One of the first uses of urea in modern medicine was the topical treatment of wounds due to its proteolytic and antibacterial properties [2]. Currently, urea is widely used in dermatology. It is prescribed for the treatment of diverse dermatoses presenting with scaly and dry skin such as atopic dermatitis, ichthyosis, seborrheic dermatitis and psoriasis, among others
Urea:
1. Increases moisturization of the stratum corneum:
Urea reduces TEWL and increases water retention and the resistance of the stratum corneum against osmotic stress. Furthermore, urea can act as an endogenous humectant replacing water in low humidity conditions
2.Improves skin's barrier function and antimicrobial defense
3. Regulates epidermial proliferation:
Urea is a highly active molecule and an important regulator of epidermal structure and function. Urea plays a fundamental role in controlling keratinocyte proliferation: it decreases DNA synthesis in basal cells and prolongs the generation time of post-mitosis epidermal cells. Urea induces a reduction in cellularity, resulting in epidermal thinning
4. Increases drug penetration:
Urea can facilitate the transport of molecules such as antifungals, corticosteroids and hormones through the skin and nails. This effect seems to be secondary to increased water absorption by keratinocytes in the presence of urea and to its keratolytic action
Products with low or medium concentration (2%–20%) of urea may be indicated for routine skin care in individuals without skin disorders . Urea can decrease TEWL , increase the water content of the stratum corneum, optimize the skin barrier function and upregulate antimicrobial peptides in the skin
