ndos
6'4.5'',wide frame,acnecel,here to looksmax
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At the beginning of the thread wanted to make sure y'all that I am not justyfying any use of nicotine neither to you nor to myself.
Y'all probably heard that nicotine acts as Aromatase Inhibitor, but there are seemingly more benefits to this substance. TLDR at the end of the thread
Nicotine Inhibits Aromatase (The Enzyme Which Converts Testosterone to Estrogen)
Nicotine Blocks Brain Estrogen Synthase (Aromatase): In Vivo Positron Emission Tomography Studies in Female Baboons
"The size of the effect (more than 50% of the maximal inhibition obtained with a blocking dose of vorozole) suggests that nicotine is capable of inhibiting the activity of aromatase in the primate brain."
JCI - Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
"In choriocarcinoma cell cultures, nicotine, cotinine (a major metabolite of nicotine), and anabasine (a minor component of cigarette tobacco) all inhibited androstenedione conversion to estrogen in a dose-dependent fashion. Removal of nicotine, cotinine, and anabasine from the culture medium resulted in the complete reversal of the inhibition of aromatase."
Potential Contribution of Aromatase Inhibition to the Effects of Nicotine and Related Compounds on the Brain
"Thus, we have shown that nicotine doses producing plasma levels comparable with those found in smokers are capable of a significant but partial (∼50%) inhibition of aromatase."
Nicotine Also Directly Lowers Estrogen and Helps Clear it From the Liver
Smoking, estradiol metabolism and hormone replacement therapy. - PubMed - NCBI
"However, it has been proven that, depending on the type, duration and intensity of nicotine consumption, smoking can reduce or completely cancel the efficacy of orally administered estrogens."
"The reduction or loss of therapeutic efficacy is mainly caused by dose-dependent elevated hepatic clearance, partially in conjunction with lower estrogen levels, and has been demonstrated only with oral estrogen applications."
Nicotine raises DHT by decreasing conversion of DHT to alpha-androstanediol (estrogenic)
Nicotine and cotinine effects on 3 alpha hydroxysteroid dehydrogenase in canine prostate. - PubMed - NCBI
"The results suggest that nicotine and cotinine are competitive inhibitors of the HSD, an important enzyme involved in the metabolism of DHT and produce an accumulation of DHT."
The main culprit is that nicotine raise cortisol which is not a good thing. But the thing is that tolerance might build up, same with caffeine, meaning a reduce in a raise of cortisol.
Nicotine Increases Short Term and Working Memory Similar to Progesterone
Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor. - PubMed - NCBI
"In the present study, male Wistar rats exposed a relatively low dosage of nicotine (0.35 mg/kg every 12 h) for 14 days demonstrated improved memory performance (assessed in two separate water maze testing methods) when compared with controls. Autoradiographic experiments indicated that nicotine increased [3H]-epibatidine, [125I]-alpha-bungarotoxin and [3H]-AFDX384, but not [3H]-pirenzepine binding sites in several learning- and memory-related brain areas."
Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. - PubMed - NCBI
"Cotinine (Nicotine metabolite) reduced Aβ deposition, improved working and reference memories, and inhibited Aβ oligomerization in the brains of transgenic (Tg) 6799 AD mice."
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice. - PubMed - NCBI
"Cotinine-treated mice displayed better performance than vehicle-treated cohorts on the working memory task, the radial arm water maze test. In addition, with or without chronic stress exposure, cotinine-treated mice engaged in fewer depressive-like behaviors as assessed using the tail suspension and Porsolt's forced swim tests."
"Taken together, our results show for the first time that cotinine reduces the negative effects of stress on mood, memory, and the synapse."
Nicotinic systems and cognitive function - Springer
Nicotine Increases Bone Growth (Possibly Through Decreasing Prolactin)
Nicotine Increases Osteoblast Activity of Induced Bone Marrow Stromal Cells in a Dose-Dependent Manner: An in vitro Cell Culture Experiment
Our study demonstrated a statistically significant effect of nicotine dose on osteoblast activity in vitro.
Low level nicotine: a novel approach to reduce osteoporosis incidence. - PubMed - NCBI
Studies also indicated that the prime criminal for osteoporosis is smoking not nicotine. Moreover, low level nicotine has preventive efforts on osteoporosis by stimulating osteoblasts proliferation and differentiation. We present a hypothesis that low level nicotine may be a novel approach to reduce osteoporosis incidence.
It’s is known by most people that caffeine increases your metabolic rate too and many use caffeine pills or energy drinks for weight loss purposes for that particular reason.
Nicotine is thermogenic and has the same ability as caffeine to increase the basal metabolic rate and body temperature. It has been shown in multiple studies such as this one and this one that it produces an increase in energy expenditure of about 6-10%.
This will equal to around 10kg or 22lbs weight loss on a yearly basis if calorie consumption stays the same.
In fact, many bodybuilders use nicotine patches or gums during cutting to help burn fat and keep the metabolic rate high even while restricting calories. A combination of both caffeine and nicotine would be ideal for this purpose.
TLDR
PROS:
- Lowers endotoxin (makes you endotoxin intolerant)
- lowers estrogen (inhibits aromatase)
- increases DHT (by inhibiting its conversion to an estrogenic metabolite)
- increases youth steroids like DHEA and allopregnanolone
- increases gut motility
- has anti-bacterial and anti-viral effects
- increases dopamine profoundly
- increases resting metabolic rate by about 5-10%
CONS:
- addictive/habit forming (especially when the brain is still changing a lot)
- increases cortisol and adrenaline
- increases free fatty acid
- increases COX2
- might increase periodontal disease
Y'all probably heard that nicotine acts as Aromatase Inhibitor, but there are seemingly more benefits to this substance. TLDR at the end of the thread
Nicotine Inhibits Aromatase (The Enzyme Which Converts Testosterone to Estrogen)
Nicotine Blocks Brain Estrogen Synthase (Aromatase): In Vivo Positron Emission Tomography Studies in Female Baboons
"The size of the effect (more than 50% of the maximal inhibition obtained with a blocking dose of vorozole) suggests that nicotine is capable of inhibiting the activity of aromatase in the primate brain."
JCI - Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
"In choriocarcinoma cell cultures, nicotine, cotinine (a major metabolite of nicotine), and anabasine (a minor component of cigarette tobacco) all inhibited androstenedione conversion to estrogen in a dose-dependent fashion. Removal of nicotine, cotinine, and anabasine from the culture medium resulted in the complete reversal of the inhibition of aromatase."
Potential Contribution of Aromatase Inhibition to the Effects of Nicotine and Related Compounds on the Brain
"Thus, we have shown that nicotine doses producing plasma levels comparable with those found in smokers are capable of a significant but partial (∼50%) inhibition of aromatase."
Nicotine Also Directly Lowers Estrogen and Helps Clear it From the Liver
Smoking, estradiol metabolism and hormone replacement therapy. - PubMed - NCBI
"However, it has been proven that, depending on the type, duration and intensity of nicotine consumption, smoking can reduce or completely cancel the efficacy of orally administered estrogens."
"The reduction or loss of therapeutic efficacy is mainly caused by dose-dependent elevated hepatic clearance, partially in conjunction with lower estrogen levels, and has been demonstrated only with oral estrogen applications."
Nicotine raises DHT by decreasing conversion of DHT to alpha-androstanediol (estrogenic)
Nicotine and cotinine effects on 3 alpha hydroxysteroid dehydrogenase in canine prostate. - PubMed - NCBI
"The results suggest that nicotine and cotinine are competitive inhibitors of the HSD, an important enzyme involved in the metabolism of DHT and produce an accumulation of DHT."
The main culprit is that nicotine raise cortisol which is not a good thing. But the thing is that tolerance might build up, same with caffeine, meaning a reduce in a raise of cortisol.
Nicotine Increases Short Term and Working Memory Similar to Progesterone
Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor. - PubMed - NCBI
"In the present study, male Wistar rats exposed a relatively low dosage of nicotine (0.35 mg/kg every 12 h) for 14 days demonstrated improved memory performance (assessed in two separate water maze testing methods) when compared with controls. Autoradiographic experiments indicated that nicotine increased [3H]-epibatidine, [125I]-alpha-bungarotoxin and [3H]-AFDX384, but not [3H]-pirenzepine binding sites in several learning- and memory-related brain areas."
Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. - PubMed - NCBI
"Cotinine (Nicotine metabolite) reduced Aβ deposition, improved working and reference memories, and inhibited Aβ oligomerization in the brains of transgenic (Tg) 6799 AD mice."
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice. - PubMed - NCBI
"Cotinine-treated mice displayed better performance than vehicle-treated cohorts on the working memory task, the radial arm water maze test. In addition, with or without chronic stress exposure, cotinine-treated mice engaged in fewer depressive-like behaviors as assessed using the tail suspension and Porsolt's forced swim tests."
"Taken together, our results show for the first time that cotinine reduces the negative effects of stress on mood, memory, and the synapse."
Nicotinic systems and cognitive function - Springer
Nicotine Increases Bone Growth (Possibly Through Decreasing Prolactin)
Nicotine Increases Osteoblast Activity of Induced Bone Marrow Stromal Cells in a Dose-Dependent Manner: An in vitro Cell Culture Experiment
Our study demonstrated a statistically significant effect of nicotine dose on osteoblast activity in vitro.
Low level nicotine: a novel approach to reduce osteoporosis incidence. - PubMed - NCBI
Studies also indicated that the prime criminal for osteoporosis is smoking not nicotine. Moreover, low level nicotine has preventive efforts on osteoporosis by stimulating osteoblasts proliferation and differentiation. We present a hypothesis that low level nicotine may be a novel approach to reduce osteoporosis incidence.
Nicotine's Effects on Metabolism
One of the primary benefits of nicotine besides its nootropic qualities is its ability to increase one's metabolic rate.It’s is known by most people that caffeine increases your metabolic rate too and many use caffeine pills or energy drinks for weight loss purposes for that particular reason.
Nicotine is thermogenic and has the same ability as caffeine to increase the basal metabolic rate and body temperature. It has been shown in multiple studies such as this one and this one that it produces an increase in energy expenditure of about 6-10%.
This will equal to around 10kg or 22lbs weight loss on a yearly basis if calorie consumption stays the same.
In fact, many bodybuilders use nicotine patches or gums during cutting to help burn fat and keep the metabolic rate high even while restricting calories. A combination of both caffeine and nicotine would be ideal for this purpose.
TLDR
PROS:
- Lowers endotoxin (makes you endotoxin intolerant)
- lowers estrogen (inhibits aromatase)
- increases DHT (by inhibiting its conversion to an estrogenic metabolite)
- increases youth steroids like DHEA and allopregnanolone
- increases gut motility
- has anti-bacterial and anti-viral effects
- increases dopamine profoundly
- increases resting metabolic rate by about 5-10%
CONS:
- addictive/habit forming (especially when the brain is still changing a lot)
- increases cortisol and adrenaline
- increases free fatty acid
- increases COX2
- might increase periodontal disease
