Jeww
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Y?
pessemistic said its the stress that closes it
Accutane decreases igf-1, it doesn't close plates. I've heard that decreasing the igf-1 is not the primary reason that it destroys acne so maybe hgh+accutane is legit?Title
Tbh I think waiting is a better choice, I wouldn't wanna risk it ykAccutane decreases igf-1, it doesn't close plates. I've heard that decreasing the igf-1 is not the primary reason that it destroys acne so maybe hgh+accutane is legit?
igf-1 causes acne primarily by women, so thats certainly not the caseAccutane decreases igf-1, it doesn't close plates. I've heard that decreasing the igf-1 is not the primary reason that it destroys acne so maybe hgh+accutane is legit?
It can cause premature closure of growth plates as a side effect. If it were solely due to its impact on IGF-1, it would slow down growth, but that's not commonly reported.Accutane decreases igf-1, it doesn't close plates. I've heard that decreasing the igf-1 is not the primary reason that it destroys acne so maybe hgh+accutane is legit?
Isotretinoin-induced premature epiphyseal closure and growth plate deformities seem to be linked to higher doses of isotretinoin for the duration of months to years. There have been reported cases of premature epiphyseal closure in individuals receiving therapeutic doses of isotretinoin for acne treatment, which are much lower compared to the high doses utilized for neuroblastoma. Based on this study, isotretinoin appears to impact the growth plates of proximal tibia and distal femur.
Doesn't seem common:It can cause premature closure of growth plates as a side effect. If it were solely due to its impact on IGF-1, it would slow down growth, but that's not commonly reported.
The growth plates in the tibia and femur are crucial for height as they contribute by a lot to longitudinal bone growth during childhood and adolescence.Analysis of the effects of isotretinoin on the premature epiphyseal closure in pediatric populations: a literature review - PubMed
Isotretinoin-induced premature epiphyseal closure and growth plate deformities seem to be linked to higher doses of isotretinoin for the duration of months to years. There have been reported cases of premature epiphyseal closure in individuals receiving therapeutic doses of isotretinoin for acne...pubmed.ncbi.nlm.nih.gov
In women, in men it's mainly DHT and Androstenedione so finasteride would be more legit depending on OPs age ofcigf-1 causes acne primarily by women, so thats certainly not the case
So the chances of plate closure are really low?Doesn't seem common:
"The FDA received 41 reports worldwide of premature epiphyseal closure related to isotretinoin in patients under 18 years of age. Additionally, premature epiphyseal closure and growth plate abnormalities occurred in nine patients with various durations and doses of isotretinoin ranging from the lowest dose of 0.5 mg/kg/day for a few months to 3.5 mg/kg/day for years."
So the chances of plate closure are really low?
probably, i wouldn;'t take it without some igf-1 booster tho. Maybe pair your hgh booster with slin pills (insulin mimetic) so you produce more igf-1 from the hgh. This would maybe offset the accutane effects on igf-1. Although finasteride is safer if you are tanner stage 5 (don't fall for "post finasteride syndrome" fearmongering)So the chances of plate closure are really low?
What are you talking about, its much more complicated then this idea of "muhh high "specific hormone" = acne"In women, in men it's mainly DHT and Androstenedionel
yeah, these specific hormones cause acne IF you are predisposed to it genetically. If u have good skin genes it doesn't matterWhat are you talking about, its much more complicated then "muhh high "specific hormone" = acne"
Yes, still a notable risk though, even on this forum a lot of users who used accutane in the past mentioned this side effect.Doesn't seem common:
"The FDA received 41 reports worldwide of premature epiphyseal closure related to isotretinoin in patients under 18 years of age. Additionally, premature epiphyseal closure and growth plate abnormalities occurred in nine patients with various durations and doses of isotretinoin ranging from the lowest dose of 0.5 mg/kg/day for a few months to 3.5 mg/kg/day for years."
No it also damages growth plates especially by the femurAccutane decreases igf-1, it doesn't close plates. I've heard that decreasing the igf-1 is not the primary reason that it destroys acne so maybe hgh+accutane is legit?
No, the mechanism of action by which accutane fuses growth plates is unrelated to anything an AI would do.Title
Why the femur specifically? Send article.No it also damages growth plates especially by the femur
Accutane not only decreases igf1 but also closes plates, and just an a bonus it decreases testosterone and overall fertility too, oh and whats more, it can decrease IQ. Fucking horrible scam drug. If you want to spin the wheel with some horrible life changing side effect then take it.Accutane decreases igf-1, it doesn't close plates. I've heard that decreasing the igf-1 is not the primary reason that it destroys acne so maybe hgh+accutane is legit?
I’m not your personal encyclopedia broWhy the femur specifically? Send article.
If you make a claim be ready to back it up. Accutane fuses plates but it doesnt target the femur specifically.I’m not your personal encyclopedia bro
The FDA realizes this about Accutane
there's nothing for me to gain by being your personal encylopediaIf you make a claim be ready to back it up. Accutane fuses plates but it doesnt target the femur specifically.