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This thread will cover more or less everything about Leuprolide Acetate.
I dont encourage anyone to do anything. This is for eduation only.
๐๐ฃ๐ฉ๐ง๐ค๐๐ช๐๐ฉ๐๐ค๐ฃ :
Leuprolide acetate, a synthetic analogue of gonadotropin-releasing hormone (GnRH)**, plays a crucial role in modulating hormone levels to influence growth patterns. Its complex mechanism of action involves suppressing gonadotropins, thereby inhibiting the production of sex hormones.
๐๐๐๐๐๐ฃ๐๐จ๐ข ๐ค๐ ๐ผ๐๐ฉ๐๐ค๐ฃ :
Leuprolide acetate works by desensitizing the GnRH receptors in the pituitary gland, leading to a temporary decrease in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This suppression ultimately reduces the production of testosterone in males and estrogen in females.
๐๐ง๐ค๐ก๐ค๐ฃ๐๐๐ ๐๐ง๐ค๐ฌ๐ฉ๐ ๐๐ก๐๐ฉ๐ ๐ผ๐๐ฉ๐๐ซ๐๐ฉ๐ฎ :
The ability of leuprolide acetate to keep growth plates open longer than usual stems from its inhibition of LH and FSH. In normal children, this prolongs the pubertal growth phase, allowing for increased linear growth.
-Studies show a significant increase in final height compared to untreated controls.
-Height gain is also more pronounced in children with a longer treatment duration.
๐ผ๐๐ข๐๐ฃ๐๐จ๐ฉ๐ง๐๐ฉ๐๐ค๐ฃ ๐๐ฃ๐ ๐ฟ๐ค๐จ๐๐๐ :
-Varied formulations:
Injectable depot (suspension or microspheres)
Intranasal spray
Implant
( Bioavailability and half-life vary depending on the route of administration. For example, depot injections have a prolonged half-life, requiring less frequent administrations compared to intranasal sprays. In addition, leuprolide acetate is metabolized primarily by the enzyme peptidase, and its elimination occurs primarily through the kidneys )
-Dosage:
Individualized based on age, sex, body weight, and treatment goals
Typically 3.75mg to 30mg every 1 to 4 months.
i advice you to take 15 mg IM once a month.
๐๐ฎ๐ฃ๐๐ง๐๐ฎ ๐ฌ๐๐ฉ๐ ๐๐ง๐ค๐ฌ๐ฉ๐ ๐๐ค๐ง๐ข๐ค๐ฃ๐ (๐๐) ๐จ๐๐๐ข ๐๐ฃ๐ฉ๐ง๐๐จ๐ฉ๐๐ฃ๐ :
-Complementary mechanisms:
Leuprolide acetate increases the availability of growth hormone by suppressing somatostatin
hGH stimulates chondrogenesis and bone growth
-Enhanced clinical outcomes:
Greater height gain compared to either treatment alone
Improved body composition and muscle mass
Reduced side effects
-a studie on this : "Research published in the Journal of Clinical Endocrinology & Metabolism demonstrated that the combined therapy of leuprolide acetate and GH resulted in significantly greater height gains compared to GH therapy alone in children with idiopathic short stature"
๐๐ฃ๐๐ง๐๐๐จ๐๐ ๐ผ๐๐ช๐ก๐ฉ ๐๐๐๐๐๐ฉ :
By delaying puberty and prolonging growth plate activity, leuprolide acetate allows for continued linear growth, ultimately contributing to increased adult height. This effect is particularly pronounced in individuals who start treatment at a younger age, as it maximizes the duration of growth potential.
๐๐ง๐๐ซ๐๐ฃ๐ฉ๐๐ฃ๐ ๐๐ง๐ค๐ฌ๐ฉ๐ ๐๐๐ก๐ค๐๐๐ฉ๐ฎ ๐ฟ๐๐๐ก๐๐ฃ๐:
To mitigate the potential decrease in growth velocity resulting from decreased LH levels, careful monitoring and dose adjustments is necessary. Close supervision by healthcare providers ensures that treatment maintains an optimal balance between delaying puberty and promoting linear growth.( even tho we know you wont do it )
๐๐๐ฉ๐๐๐๐ฉ๐๐ฃ๐ ๐ฉ๐๐ ๐๐๐๐๐๐ฉ๐จ ๐ค๐ ๐ก๐ช๐ฉ๐๐๐ฃ๐๐ฏ๐๐ฃ๐ ๐๐ค๐ง๐ข๐ค๐ฃ๐ (๐๐) ๐จ๐ช๐ฅ๐ฅ๐ง๐๐จ๐จ๐๐ค๐ฃ :
-LH role in bone health:
Stimulates osteoblast activity and bone formation
-Leuprolide acetate-induced LH suppression:
May lead to decreased bone mineral density
-Strategies to mitigate bone loss:
Calcium and vitamin D supplementation
Weight-bearing exercises
Bisphosphonate therapy
**GnRH is a natural hormone that stimulates the pituitary gland to release LH and FSH
THANK YOU FOR READING !
-----------------------------
additional information :
(Supporting Study)
1 : A study published in the Journal of Clinical Endocrinology & Metabolism found that leuprolide acetate significantly delayed bone age advancement in children with central precocious puberty, demonstrating its efficacy in preserving growth potential.
2 : Leuprolide acetate treatment in children with precocious puberty led to a significant increase in final height compared to controls.
3 : The combination of leuprolide acetate and hGH in children with short stature resulted in greater height gain and improved body composition than hGH alone.
( I have a very hight numbers of studies, therefore i wont put them all )
@dannydipss @Rigged @mogpending @SkullDynamics @Osie
I dont encourage anyone to do anything. This is for eduation only.
๐๐ฃ๐ฉ๐ง๐ค๐๐ช๐๐ฉ๐๐ค๐ฃ :
Leuprolide acetate, a synthetic analogue of gonadotropin-releasing hormone (GnRH)**, plays a crucial role in modulating hormone levels to influence growth patterns. Its complex mechanism of action involves suppressing gonadotropins, thereby inhibiting the production of sex hormones.
๐๐๐๐๐๐ฃ๐๐จ๐ข ๐ค๐ ๐ผ๐๐ฉ๐๐ค๐ฃ :
Leuprolide acetate works by desensitizing the GnRH receptors in the pituitary gland, leading to a temporary decrease in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This suppression ultimately reduces the production of testosterone in males and estrogen in females.
๐๐ง๐ค๐ก๐ค๐ฃ๐๐๐ ๐๐ง๐ค๐ฌ๐ฉ๐ ๐๐ก๐๐ฉ๐ ๐ผ๐๐ฉ๐๐ซ๐๐ฉ๐ฎ :
The ability of leuprolide acetate to keep growth plates open longer than usual stems from its inhibition of LH and FSH. In normal children, this prolongs the pubertal growth phase, allowing for increased linear growth.
-Studies show a significant increase in final height compared to untreated controls.
-Height gain is also more pronounced in children with a longer treatment duration.
๐ผ๐๐ข๐๐ฃ๐๐จ๐ฉ๐ง๐๐ฉ๐๐ค๐ฃ ๐๐ฃ๐ ๐ฟ๐ค๐จ๐๐๐ :
-Varied formulations:
Injectable depot (suspension or microspheres)
Intranasal spray
Implant
( Bioavailability and half-life vary depending on the route of administration. For example, depot injections have a prolonged half-life, requiring less frequent administrations compared to intranasal sprays. In addition, leuprolide acetate is metabolized primarily by the enzyme peptidase, and its elimination occurs primarily through the kidneys )
-Dosage:
Individualized based on age, sex, body weight, and treatment goals
Typically 3.75mg to 30mg every 1 to 4 months.
i advice you to take 15 mg IM once a month.
๐๐ฎ๐ฃ๐๐ง๐๐ฎ ๐ฌ๐๐ฉ๐ ๐๐ง๐ค๐ฌ๐ฉ๐ ๐๐ค๐ง๐ข๐ค๐ฃ๐ (๐๐) ๐จ๐๐๐ข ๐๐ฃ๐ฉ๐ง๐๐จ๐ฉ๐๐ฃ๐ :
-Complementary mechanisms:
Leuprolide acetate increases the availability of growth hormone by suppressing somatostatin
hGH stimulates chondrogenesis and bone growth
-Enhanced clinical outcomes:
Greater height gain compared to either treatment alone
Improved body composition and muscle mass
Reduced side effects
-a studie on this : "Research published in the Journal of Clinical Endocrinology & Metabolism demonstrated that the combined therapy of leuprolide acetate and GH resulted in significantly greater height gains compared to GH therapy alone in children with idiopathic short stature"
๐๐ฃ๐๐ง๐๐๐จ๐๐ ๐ผ๐๐ช๐ก๐ฉ ๐๐๐๐๐๐ฉ :
By delaying puberty and prolonging growth plate activity, leuprolide acetate allows for continued linear growth, ultimately contributing to increased adult height. This effect is particularly pronounced in individuals who start treatment at a younger age, as it maximizes the duration of growth potential.
๐๐ง๐๐ซ๐๐ฃ๐ฉ๐๐ฃ๐ ๐๐ง๐ค๐ฌ๐ฉ๐ ๐๐๐ก๐ค๐๐๐ฉ๐ฎ ๐ฟ๐๐๐ก๐๐ฃ๐:
To mitigate the potential decrease in growth velocity resulting from decreased LH levels, careful monitoring and dose adjustments is necessary. Close supervision by healthcare providers ensures that treatment maintains an optimal balance between delaying puberty and promoting linear growth.( even tho we know you wont do it )
๐๐๐ฉ๐๐๐๐ฉ๐๐ฃ๐ ๐ฉ๐๐ ๐๐๐๐๐๐ฉ๐จ ๐ค๐ ๐ก๐ช๐ฉ๐๐๐ฃ๐๐ฏ๐๐ฃ๐ ๐๐ค๐ง๐ข๐ค๐ฃ๐ (๐๐) ๐จ๐ช๐ฅ๐ฅ๐ง๐๐จ๐จ๐๐ค๐ฃ :
-LH role in bone health:
Stimulates osteoblast activity and bone formation
-Leuprolide acetate-induced LH suppression:
May lead to decreased bone mineral density
-Strategies to mitigate bone loss:
Calcium and vitamin D supplementation
Weight-bearing exercises
Bisphosphonate therapy
**GnRH is a natural hormone that stimulates the pituitary gland to release LH and FSH
THANK YOU FOR READING !
-----------------------------
additional information :
(Supporting Study)
1 : A study published in the Journal of Clinical Endocrinology & Metabolism found that leuprolide acetate significantly delayed bone age advancement in children with central precocious puberty, demonstrating its efficacy in preserving growth potential.
2 : Leuprolide acetate treatment in children with precocious puberty led to a significant increase in final height compared to controls.
3 : The combination of leuprolide acetate and hGH in children with short stature resulted in greater height gain and improved body composition than hGH alone.
( I have a very hight numbers of studies, therefore i wont put them all )
@dannydipss @Rigged @mogpending @SkullDynamics @Osie
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