Youㅤ
seriousmaxxing , only talk serious
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As a devoted anti-ageing scientist, I decided to reconsider the utility of prolonged fasting for the purpose of anti-ageing, for I have realized that I must question everything. Most people think in simple terms , like "exercise good" and "sugar bad" , when reality is actually extremely nuanced , AND so many common notions are generally wrong, like "red meat bad" . I have done prolonged fasting in the past for "stem cells" without understanding the theory . I now recognize that you cannot trust your intuition , jews have reprogrammed ur intuition consciously and subconsciously . Perhaps , for most people , the perception that fasting is anti ageing is deep rooted in the fallacy of "being healthy means discipline" (ex. vegetables , exercise , and maybe starvemaxxing too ?!) , although people consciously rationalize fasting with "autophagy" . I have devised a mechanistic theory of stem cell ageing based on my reading .
You's Theory of stem cell ageing: Asymmetric stem cell division has the benefit of utilizeing the premise of the immortal strand hypothesis so that the new chromatin is attributed to the differentiated cell to preserve the mutation-free DNA of stem cell pools. With age, JNK increases, augmenting stem cell orientation of the spindles so that differentiation is more often self-renewal. This can prevent stem cell pools from diminishing with age, which can happen due to senescence of stem cells or apoptosis. However, this leads to dysplasia of tissues and also the ageing of stem cell pools by preventing utilization of the premise of the immortal strand hypothesis. The stem cell pools accumulate mutations and this leads to abnormal differentiated cells and potentially tumorigenesis (generation of tumor).
Prolonged fasting (PF) promotes stem cell self-renewal , at least in hematopoietic stem cells (Cheng et al) , which is division of a stem cell into two stem cells . Self renewal is problematic because in cell division , the DNA is duplicated , but the new DNA could have errors . Stem cells in youth utilize asymmetric division, which means they split into one stem cell and one differentiated cell, more than in older age (Florian et al) The immortal strand hypothesis , proposed in 1975 by John Cairns , is that stem cells preferentially attribute the new copy of DNA (and thus potentially mutated) to the differentiated cell rather than the stem cell when undergoing asymmetric division .
But is the immortal strand hypothesis supported ? Sotiropoulou et al have demonstrated that the new chromatin was randomly distributed in mouse hair follicle stem cells in vivo . However , the immortal strand hypothesis has been supported in neural stem cells and muscle satellite stem cells (Karpowics et all) (Shinin et al) (Conboy et al) (Ferron et al) . I would not consider the hypothesis disproven , and it's my opinion that it occurs to at least some degree . Would be nice to have more data .
This makes sense to me now , fasting puts the body into starvation mode . it has a poor supply of energy and so it makes compromises . Prolonged fasting puts the body out of a "pro-stemness" mode and into a "pro-function" mode . The rejuvenation from fasting is a short-term benefit I speculate in terms of stem cells . Stem cell proliferation during fasting , or elsetime , is a pro-function activity . For longevity , a pro-stemness state is optimal , u want ur stem cells in quiescence , or dormancy .
Forced proliferation of stem cells (based on the immortal strand hypothesis , self-renewal aged stem cells more) accelerates ageing . Canonical Wnt signalling promotes stem cell self renewal , but overactivation leads to premature senescence of epidermal stem cells in transgenic mice (Castilho et al) .
My perception now from a stem cell based perspective is that prolonged fasting puts stem cells into a pro-function mode and recycles tissues , leading to a short term rejuvenation , but long term ageing . Now , I want to make it clear that this is a stem cell based perspective , and i am interested to hear opinions from an "autophagy" based perspective or a growth/fecundity inhibition perspective .
You's Theory of stem cell ageing: Asymmetric stem cell division has the benefit of utilizeing the premise of the immortal strand hypothesis so that the new chromatin is attributed to the differentiated cell to preserve the mutation-free DNA of stem cell pools. With age, JNK increases, augmenting stem cell orientation of the spindles so that differentiation is more often self-renewal. This can prevent stem cell pools from diminishing with age, which can happen due to senescence of stem cells or apoptosis. However, this leads to dysplasia of tissues and also the ageing of stem cell pools by preventing utilization of the premise of the immortal strand hypothesis. The stem cell pools accumulate mutations and this leads to abnormal differentiated cells and potentially tumorigenesis (generation of tumor).
Prolonged fasting (PF) promotes stem cell self-renewal , at least in hematopoietic stem cells (Cheng et al) , which is division of a stem cell into two stem cells . Self renewal is problematic because in cell division , the DNA is duplicated , but the new DNA could have errors . Stem cells in youth utilize asymmetric division, which means they split into one stem cell and one differentiated cell, more than in older age (Florian et al) The immortal strand hypothesis , proposed in 1975 by John Cairns , is that stem cells preferentially attribute the new copy of DNA (and thus potentially mutated) to the differentiated cell rather than the stem cell when undergoing asymmetric division .
But is the immortal strand hypothesis supported ? Sotiropoulou et al have demonstrated that the new chromatin was randomly distributed in mouse hair follicle stem cells in vivo . However , the immortal strand hypothesis has been supported in neural stem cells and muscle satellite stem cells (Karpowics et all) (Shinin et al) (Conboy et al) (Ferron et al) . I would not consider the hypothesis disproven , and it's my opinion that it occurs to at least some degree . Would be nice to have more data .
This makes sense to me now , fasting puts the body into starvation mode . it has a poor supply of energy and so it makes compromises . Prolonged fasting puts the body out of a "pro-stemness" mode and into a "pro-function" mode . The rejuvenation from fasting is a short-term benefit I speculate in terms of stem cells . Stem cell proliferation during fasting , or elsetime , is a pro-function activity . For longevity , a pro-stemness state is optimal , u want ur stem cells in quiescence , or dormancy .
Forced proliferation of stem cells (based on the immortal strand hypothesis , self-renewal aged stem cells more) accelerates ageing . Canonical Wnt signalling promotes stem cell self renewal , but overactivation leads to premature senescence of epidermal stem cells in transgenic mice (Castilho et al) .
My perception now from a stem cell based perspective is that prolonged fasting puts stem cells into a pro-function mode and recycles tissues , leading to a short term rejuvenation , but long term ageing . Now , I want to make it clear that this is a stem cell based perspective , and i am interested to hear opinions from an "autophagy" based perspective or a growth/fecundity inhibition perspective .
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