[HIGH IQ] Key to Longer Eyelashes ( Latisse is a meme)

[bronzeagepervert]

In a six-month randomized clinical trial by Noecker et al comparing bimatoprost and latanoprost, eyelash growth was noted in 14 of 133 patients in the bimatoprost group versus no patients in the latanoprost group. Other studies by Eisenberg et al and Tosti et al have found similar results, also reporting that hypertrichosis usually appears earlier with bimatoprost than with latanoprost.
Hypertrichosis basically means excessive lash growth.

6 months for eyelash growth and yet the chances of actually noting observable eyelash growth is 1/10 th is completely disgusting. I dont know how they managed to formulate it as a cosmetic product when the results aren't even achievable consistently. Maybe its old hags who would do anything for huge eyelashes to cope with age pill.

But after reading a few studies, there's something interesting I observed.

Firstly, a word on PGF alpha 2 - the prostaglandin which is said to account for the increash in lash density observed. Remember latisse is a glaucoma medication first and foremost and works by reducing Intra Ocular pressure which is the pressure exerted by the amniotic fluid on the eyeball.

Here's what Wikipedia says about Prostaglandin F2 alpha:



Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. Because PGF2α is linked with an increase in uterine oxytocin levels, there is evidence that PGF2α and oxytocin form a positive feedback loop to facilitate the degradation of the corpus luteum. PGF2α and oxytocin also inhibit the production of progesterone, a hormone that facilitates corpus luteum development. Conversely, higher progesterone levels inhibit production of PGF2α and oxytocin, as the effects of the hormones are in opposition to each other. This is directly exhibited following ovulation when there is a spike of progesterone levels, and then as progesterone levels decrease, PGF2 levels will peak

Now this is interesting because the same signalling molecule both induces labor and is also used for abortions.

However, From PubMed:


TLDR: Wikipedia claims PGF 2 decreases progesterone, but Pub Med clarifies that this is dose dependent and that in young people the PGF -2 alpha actually induces a progesterone secretion markedly overweighing the e2 secretion (progesterone of course being antagonistic to estrogen in most of its phenotypic actions unlike what is commonly thought ie. they do not work in synergy no matter how much Bayer shills they do). Id imagine the cells making up the lower eyelid also resemble SLC more simply due to the fact that it does not need a strong barrier as much as the placenta.

We can thus infer that topical bimatoprost increases progesterone through the signal transduction of PGF 2 which led to higher progesterone concentrations in tissue.
Mechanism would go somewhat like this:
PGF 2 --> estrogen e2 stimulation --> progesterone stimulation --> eyelash growth.
This of course could all be circumvented by simply applying topical progesterone and indeed there are many reports of women who take bioidentical progesterone (not progestins which have estrogenic action) reporting major lash growth. But they take megadoses orally and I think a small topical dose would be enough for that effect.

Another interesting thing I found was that Bimatoprost wasnt alone in glaucoma medications causing lash growth. Acetozalamide which is a carbonic anhydrase inhibitor does the same by reducing intra ocular blood pressure (or through vasodilation effect consistently observed) also somehow induces lash growth? Latter mechanism would make more sense as it would mean improved blood flow prolonging the anagen phase and since lashes have the lowest anagen: telogen phase of hair follicles in the body it would benefit the most from progesterone and acetozalamide as prog has also shown to increase the duration of the anagen phase.

I dont recommend taking anything else on that list except Acetozalamide. Pencillamine seems to be safe but have not done much research. Acetozalamide with potassium to replenish the lost salts (through urine ) is the safest one.


I think topical progesterone and acetozalamide over a period of three months would be more than enough to replicate Bimatoprost's actions without any of the side effects such as periorbital fat loss, darkening of iris etc. caused by prostaglandin.

 

[bronzeagepervert]

The lowest dose of progesterone (0.001 mcg/ml) had no significant effect on estradiol accumulation in the medium. The four higher doses of progesterone suppressed estradiol secretion in a dose-dependent manner. Doses of 10, 1 and 0.1 mcg progesterone/mldecreased estradiol by about 98%, 50%, and 26%, respectively, during the second and third days of culture (P< 0.01); 0.01 mcg/ml was significantly effective only on the third day (P<0.05)."

The progesterone precursor, pregnenolone, was as effective as progesterone while the progesterone metabolite, 17a-hydroxyprogesterone, was without effect, even at a concentration of 10 pg/mI (Table 2). The reversibility of the inhibitory effect was related to dose of progesterone and length of exposure (Fig. 2). Cells did not regain the ability to respond to FSH by secreting estradiol when they had been exposed to 10 mcg/ml for 1 day or longer. In contrast, the effects of exposure to lower doses (0.1 and 1 mcg/ml) seemed fully or partially reversible, depending on the length of exposure. The irreversibility of the effects of progesterone does not seem to be due to general toxic effects on the granulosa cells, since progesterone secretion later in culture by cells exposed to progesterone early in culture did not follow the same pattern as estradiol secretion and in some cases was unaffected by progesterone treatments that completely suppressed estradiol secretion (Fig. 3).

 

[russwestbrook]

tldr

 

[dannydipss]

did read, good thread

 

[s4raw]

In a six-month randomized clinical trial by Noecker et al comparing bimatoprost and latanoprost, eyelash growth was noted in 14 of 133 patients in the bimatoprost group versus no patients in the latanoprost group. Other studies by Eisenberg et al and Tosti et al have found similar results, also reporting that hypertrichosis usually appears earlier with bimatoprost than with latanoprost.
Hypertrichosis basically means excessive lash growth.

6 months for eyelash growth and yet the chances of actually noting observable eyelash growth is 1/10 th is completely disgusting. I dont know how they managed to formulate it as a cosmetic product when the results aren't even achievable consistently. Maybe its old hags who would do anything for huge eyelashes to cope with age pill.

But after reading a few studies, there's something interesting I observed.

Firstly, a word on PGF alpha 2 - the prostaglandin which is said to account for the increash in lash density observed. Remember latisse is a glaucoma medication first and foremost and works by reducing Intra Ocular pressure which is the pressure exerted by the amniotic fluid on the eyeball.

Here's what Wikipedia says about Prostaglandin F2 alpha:



Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. Because PGF2α is linked with an increase in uterine oxytocin levels, there is evidence that PGF2α and oxytocin form a positive feedback loop to facilitate the degradation of the corpus luteum. PGF2α and oxytocin also inhibit the production of progesterone, a hormone that facilitates corpus luteum development. Conversely, higher progesterone levels inhibit production of PGF2α and oxytocin, as the effects of the hormones are in opposition to each other. This is directly exhibited following ovulation when there is a spike of progesterone levels, and then as progesterone levels decrease, PGF2 levels will peak

Now this is interesting because the same signalling molecule both induces labor and is also used for abortions.

However, From PubMed:


TLDR: Wikipedia claims PGF 2 decreases progesterone, but Pub Med clarifies that this is dose dependent and that in young people the PGF -2 alpha actually induces a progesterone secretion markedly overweighing the e2 secretion (progesterone of course being antagonistic to estrogen in most of its phenotypic actions unlike what is commonly thought ie. they do not work in synergy no matter how much Bayer shills they do). Id imagine the cells making up the lower eyelid also resemble SLC more simply due to the fact that it does not need a strong barrier as much as the placenta.

We can thus infer that topical bimatoprost increases progesterone through the signal transduction of PGF 2 which led to higher progesterone concentrations in tissue.
Mechanism would go somewhat like this:
PGF 2 --> estrogen e2 stimulation --> progesterone stimulation --> eyelash growth.
This of course could all be circumvented by simply applying topical progesterone and indeed there are many reports of women who take bioidentical progesterone (not progestins which have estrogenic action) reporting major lash growth. But they take megadoses orally and I think a small topical dose would be enough for that effect.

Another interesting thing I found was that Bimatoprost wasnt alone in glaucoma medications causing lash growth. Acetozalamide which is a carbonic anhydrase inhibitor does the same by reducing intra ocular blood pressure (or through vasodilation effect consistently observed) also somehow induces lash growth? Latter mechanism would make more sense as it would mean improved blood flow prolonging the anagen phase and since lashes have the lowest anagen: telogen phase of hair follicles in the body it would benefit the most from progesterone and acetozalamide as prog has also shown to increase the duration of the anagen phase.

I dont recommend taking anything else on that list except Acetozalamide. Pencillamine seems to be safe but have not done much research. Acetozalamide with potassium to replenish the lost salts (through urine ) is the safest one.


I think topical progesterone and acetozalamide over a period of three months would be more than enough to replicate Bimatoprost's actions without any of the side effects such as periorbital fat loss, darkening of iris etc. caused by prostaglandin.

This nigga copied @BrahminBoss thread FAGGOT ALERT NIGGAS

 

[bronzeagepervert]

bump

 

[bronzeagepervert]

This nigga copied @BrahminBoss thread FAGGOT ALERT NIGGAS

"Joined August 12, 2023"

 

[FBl]

Raped @BrahminBoss

 

[CoreSchizo]

dnr I already have long eyelashes

 

[mathis]

The lowest dose of progesterone (0.001 mcg/ml) had no significant effect on estradiol accumulation in the medium. The four higher doses of progesterone suppressed estradiol secretion in a dose-dependent manner. Doses of 10, 1 and 0.1 mcg progesterone/mldecreased estradiol by about 98%, 50%, and 26%, respectively, during the second and third days of culture (P< 0.01); 0.01 mcg/ml was significantly effective only on the third day (P<0.05)."

The progesterone precursor, pregnenolone, was as effective as progesterone while the progesterone metabolite, 17a-hydroxyprogesterone, was without effect, even at a concentration of 10 pg/mI (Table 2). The reversibility of the inhibitory effect was related to dose of progesterone and length of exposure (Fig. 2). Cells did not regain the ability to respond to FSH by secreting estradiol when they had been exposed to 10 mcg/ml for 1 day or longer. In contrast, the effects of exposure to lower doses (0.1 and 1 mcg/ml) seemed fully or partially reversible, depending on the length of exposure. The irreversibility of the effects of progesterone does not seem to be due to general toxic effects on the granulosa cells, since progesterone secretion later in culture by cells exposed to progesterone early in culture did not follow the same pattern as estradiol secretion and in some cases was unaffected by progesterone treatments that completely suppressed estradiol secretion (Fig. 3).

You dont need this. Just use castor oil and increase your test lvl

 

[s4raw]

"Joined August 12, 2023"

Nigga i joined way before you Imma touch you unethically if you keep doing this faggotry

 

[s4raw]

"Joined August 12, 2023"

Nigga i joined way before you Imma touch you unethically if you keep doing this faggotry

 

[Sushifart]

Nigga i joined way before you Imma touch you unethically if you keep doing this faggotry

Nigga i joined way before you Imma touch you unethically if you keep doing this faggotry

"Joined August 12, 2023"

You know he means it because he said it twice. Pucker up your asshole, little man, and don't say I didn't warn you. When the beast is hungry, he feasts.

 

[vzidel]

good thread

 

[starvecell]

Just buy a curler bro..

 

[prince_]

wtf just use castor oil and your lashes will grow in like 3 weeks

 

[mirrormogger]

 

[Luh?nn?]

Why did you copy the another guys thread?

 

[Thebbcmaxxer]

tldr

something about estrogen so soy = good

 

[bronzeagepervert]

Nigga i joined way before you Imma touch you unethically if you keep doing this faggotry

Whyd you have to say it twice retard?

 

[bronzeagepervert]

Why did you copy the another guys thread?
View attachment 2819109

He copied me

 

[albanian_chad]

In a six-month randomized clinical trial by Noecker et al comparing bimatoprost and latanoprost, eyelash growth was noted in 14 of 133 patients in the bimatoprost group versus no patients in the latanoprost group. Other studies by Eisenberg et al and Tosti et al have found similar results, also reporting that hypertrichosis usually appears earlier with bimatoprost than with latanoprost.
Hypertrichosis basically means excessive lash growth.

6 months for eyelash growth and yet the chances of actually noting observable eyelash growth is 1/10 th is completely disgusting. I dont know how they managed to formulate it as a cosmetic product when the results aren't even achievable consistently. Maybe its old hags who would do anything for huge eyelashes to cope with age pill.

But after reading a few studies, there's something interesting I observed.

Firstly, a word on PGF alpha 2 - the prostaglandin which is said to account for the increash in lash density observed. Remember latisse is a glaucoma medication first and foremost and works by reducing Intra Ocular pressure which is the pressure exerted by the amniotic fluid on the eyeball.

Here's what Wikipedia says about Prostaglandin F2 alpha:



Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. Because PGF2α is linked with an increase in uterine oxytocin levels, there is evidence that PGF2α and oxytocin form a positive feedback loop to facilitate the degradation of the corpus luteum. PGF2α and oxytocin also inhibit the production of progesterone, a hormone that facilitates corpus luteum development. Conversely, higher progesterone levels inhibit production of PGF2α and oxytocin, as the effects of the hormones are in opposition to each other. This is directly exhibited following ovulation when there is a spike of progesterone levels, and then as progesterone levels decrease, PGF2 levels will peak

Now this is interesting because the same signalling molecule both induces labor and is also used for abortions.

However, From PubMed:


TLDR: Wikipedia claims PGF 2 decreases progesterone, but Pub Med clarifies that this is dose dependent and that in young people the PGF -2 alpha actually induces a progesterone secretion markedly overweighing the e2 secretion (progesterone of course being antagonistic to estrogen in most of its phenotypic actions unlike what is commonly thought ie. they do not work in synergy no matter how much Bayer shills they do). Id imagine the cells making up the lower eyelid also resemble SLC more simply due to the fact that it does not need a strong barrier as much as the placenta.

We can thus infer that topical bimatoprost increases progesterone through the signal transduction of PGF 2 which led to higher progesterone concentrations in tissue.
Mechanism would go somewhat like this:
PGF 2 --> estrogen e2 stimulation --> progesterone stimulation --> eyelash growth.
This of course could all be circumvented by simply applying topical progesterone and indeed there are many reports of women who take bioidentical progesterone (not progestins which have estrogenic action) reporting major lash growth. But they take megadoses orally and I think a small topical dose would be enough for that effect.

Another interesting thing I found was that Bimatoprost wasnt alone in glaucoma medications causing lash growth. Acetozalamide which is a carbonic anhydrase inhibitor does the same by reducing intra ocular blood pressure (or through vasodilation effect consistently observed) also somehow induces lash growth? Latter mechanism would make more sense as it would mean improved blood flow prolonging the anagen phase and since lashes have the lowest anagen: telogen phase of hair follicles in the body it would benefit the most from progesterone and acetozalamide as prog has also shown to increase the duration of the anagen phase.

I dont recommend taking anything else on that list except Acetozalamide. Pencillamine seems to be safe but have not done much research. Acetozalamide with potassium to replenish the lost salts (through urine ) is the safest one.


I think topical progesterone and acetozalamide over a period of three months would be more than enough to replicate Bimatoprost's actions without any of the side effects such as periorbital fat loss, darkening of iris etc. caused by prostaglandin.

just be ethnic jfl

 

[Thefaqeeh]

can we use topicl minox on eyrs?

 

[truecel12]

In a six-month randomized clinical trial by Noecker et al comparing bimatoprost and latanoprost, eyelash growth was noted in 14 of 133 patients in the bimatoprost group versus no patients in the latanoprost group. Other studies by Eisenberg et al and Tosti et al have found similar results, also reporting that hypertrichosis usually appears earlier with bimatoprost than with latanoprost.
Hypertrichosis basically means excessive lash growth.

6 months for eyelash growth and yet the chances of actually noting observable eyelash growth is 1/10 th is completely disgusting. I dont know how they managed to formulate it as a cosmetic product when the results aren't even achievable consistently. Maybe its old hags who would do anything for huge eyelashes to cope with age pill.

But after reading a few studies, there's something interesting I observed.

Firstly, a word on PGF alpha 2 - the prostaglandin which is said to account for the increash in lash density observed. Remember latisse is a glaucoma medication first and foremost and works by reducing Intra Ocular pressure which is the pressure exerted by the amniotic fluid on the eyeball.

Here's what Wikipedia says about Prostaglandin F2 alpha:



Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. Because PGF2α is linked with an increase in uterine oxytocin levels, there is evidence that PGF2α and oxytocin form a positive feedback loop to facilitate the degradation of the corpus luteum. PGF2α and oxytocin also inhibit the production of progesterone, a hormone that facilitates corpus luteum development. Conversely, higher progesterone levels inhibit production of PGF2α and oxytocin, as the effects of the hormones are in opposition to each other. This is directly exhibited following ovulation when there is a spike of progesterone levels, and then as progesterone levels decrease, PGF2 levels will peak

Now this is interesting because the same signalling molecule both induces labor and is also used for abortions.

However, From PubMed:


TLDR: Wikipedia claims PGF 2 decreases progesterone, but Pub Med clarifies that this is dose dependent and that in young people the PGF -2 alpha actually induces a progesterone secretion markedly overweighing the e2 secretion (progesterone of course being antagonistic to estrogen in most of its phenotypic actions unlike what is commonly thought ie. they do not work in synergy no matter how much Bayer shills they do). Id imagine the cells making up the lower eyelid also resemble SLC more simply due to the fact that it does not need a strong barrier as much as the placenta.

We can thus infer that topical bimatoprost increases progesterone through the signal transduction of PGF 2 which led to higher progesterone concentrations in tissue.
Mechanism would go somewhat like this:
PGF 2 --> estrogen e2 stimulation --> progesterone stimulation --> eyelash growth.
This of course could all be circumvented by simply applying topical progesterone and indeed there are many reports of women who take bioidentical progesterone (not progestins which have estrogenic action) reporting major lash growth. But they take megadoses orally and I think a small topical dose would be enough for that effect.

Another interesting thing I found was that Bimatoprost wasnt alone in glaucoma medications causing lash growth. Acetozalamide which is a carbonic anhydrase inhibitor does the same by reducing intra ocular blood pressure (or through vasodilation effect consistently observed) also somehow induces lash growth? Latter mechanism would make more sense as it would mean improved blood flow prolonging the anagen phase and since lashes have the lowest anagen: telogen phase of hair follicles in the body it would benefit the most from progesterone and acetozalamide as prog has also shown to increase the duration of the anagen phase.

I dont recommend taking anything else on that list except Acetozalamide. Pencillamine seems to be safe but have not done much research. Acetozalamide with potassium to replenish the lost salts (through urine ) is the safest one.


I think topical progesterone and acetozalamide over a period of three months would be more than enough to replicate Bimatoprost's actions without any of the side effects such as periorbital fat loss, darkening of iris etc. caused by prostaglandin.