How over is it if I stopped being able to enjoy drugs even?

[TsarTsar444]

Thanks for the info, mirin iq. I'm planning to switch from mirta to bupropion. Do you know how bupro interacts with amph? It's inhibits reuptake of norepinephrine and dopamine so guess it will also kill amph euphoria?

Now bupropion for some reason seems wierd as in there are mixed opinions subjectively from users that it either blocks or enhances effects which is peculiar. The reason mitra does it is because of increased seratonin as well which acts inhibitory on dopaminergic and norepinephrine pleasure pathways for seeking out "dangerous and reckless activities", it is a mood stabilizer for a reason, it is supposed to blunt euphoria. Buprion only inhibits neurotransmitters in the prefrontal cortex, and why it is helpful in cigarette cessation. Also its the safest anti depressant with no risky post use syndroms, you could easily test it out without worry on its own

 

[apocalypse]

Now bupropion for some reason seems wierd as in there are mixed opinions subjectively from users that it either blocks or enhances effects which is peculiar. The reason mitra does it is because of increased seratonin as well which acts inhibitory on dopaminergic and norepinephrine pleasure pathways for seeking out "dangerous and reckless activities", it is a mood stabilizer for a reason, it is supposed to blunt euphoria. Buprion only inhibits neurotransmitters in the prefrontal cortex, and why it is helpful in cigarette cessation. Also its the safest anti depressant with no risky post use syndroms, you could easily test it out without worry on its own

this bullshit mirta seems to also completely block shrooms fml

 

[radicalrationalist]

no amount of drugs can compare to the pleasure/sensation of scoping out a remote trap house with thermal scopes, staking it out solo for days/weeks, waiting till everyone is gone, then going in under the cover of a moonless night using night vision monocular and taking everything of value. i can imagine the heightened pleasure one might get if they used tannerite or some other kind of primary explosive and waited till all the shitskins and pendejos returned to detonate it