SkullDynamics
Future endocrinologist
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HOW TO GROW LIKE A WILD FUNGUS
A SkullDynamics Guide
A SkullDynamics Guide
DISCLAIMER
Closed plate cel trying to heightmaxx? GTFO.
Gymcels and openplatecels GTFIH
INTRODUCTIONIn this thread i will explain how these growth factors and androgens affect skeletal development, induce sexual dimorphism, muscle growth and vertical growth. I will begin with explaining the biological mechanisms of these hormones and how you can apply them.
THE GROWTH FACTORS
1. IGF-1 LR3
2. PEG MGF
IGF-1 FOR LOWIQCELS
IGF-1, otherwise known as Insulin-like Growth Factor, is a peptide displaying structural and functional similarities to insulin. It is produced in liver via growth hormone and demonstrates both direct & indirect anabolic activity through several distinct mechanisms, as well as anti-catabolic effects. In addition, IGF-1 is what's known as a cell differentiator. Differentiation is the process of signaling an immature stem cell to become a specialized cell type and in the case of IGF-1, the cell type being created is that of muscle or bone by osteblasts. These newly formed cells will remain those permanently and retain the ability to hypertrophy, produce more affinity of creating osteoblasts to the same degree as previously existing cells.
The process of turning a stem cell into a muscle cell is known as hyperplasia. Hyperplasia varies from muscle cell hypertrophy, in that hypertrophy is simply the growth of previously existing muscle cells, while hyperplasia leads to an actual increase in the number of muscle cells present. IGF-1 works hand in hand with MGF, in order to carry out the process of hyperplasia. MGF initiates this process through cell proliferation, which is the formation of new stem cells. Once these new stem cells have been manufactured, IGF-1 can then perform its function of differentiation, completing the process of hyperplasia
Due to IGF-1?s functional similarities to insulin, IGF-1 increases the rate and degree of nutrient transport into muscle cells, resulting in an increase in protein synthesis and a subsequent increase in muscle fullness. IGF-1 also acts as an inhibitor of muscle cell apoptosis and is involved in the growth of multiple cell lines in the body. Higher levels of IGF-1 are correlated with increased amounts of lean muscle tissue and decreased fat mass, which is well documented in both human and animal study subjects.
Today, IGF-1 is produced in multiple forms, such as standard IGF-1, IGF-1 LR3, and DES IGF-1. The LR3 version mentioned in this article is the longest acting form of IGF-1 and is over twice as anabolic, per mcg, than regular IGF-1. IGF-1 LR3 stays active in the body for roughly 24 hours, allowing for once daily dosing. Of all the IGF-1?s available in the marketplace today, the LR3 version is generally preferred by those looking for a whole-body "recomp" and as such, has become one of the most popular forms of IGF-1 in the BB'ing community.
BENEFITS OF IGF-1 LR3
Increased muscle growth - Decreased body fat- Increased nutrient shuttling capacity- Increased muscle pumps - Increased muscle fullness - The ability to cause muscle cell hyperplasia - Regeneration of nerve tissue - Bone Growth
SIDE EFFECTS (PUSSYCELS GTFO)
* Potential hypoglycemia (low blood sugar) at higher dosages (not typically a concern at normal dosages).
* There have not yet been any studies examining the long-term effects of IGF-1 in humans, as is the case with most performance enhancing drugs. In terms of real-world experience, the IGF-1 class of drugs appear to maintain a rather mild disposition, having demonstrated a low side effect profile in users. Aside from possible hypoglycemia at higher dosages (which is due to the positive nutrient shuttling effects of the drug and easily rectified through the consumption of any nutrient able to elevate blood glucose), IGF-1 LR3 has been largely absent of any outward negative side effects. At this juncture, it is not unreasonable to assume that the IGF-1 category of drugs is significantly more benign in nature than AAS.
* IGF-1 LR3 Will grow EVERYTHING. Skull, feet, hands, frame, hip, penis, organs, skin and hair.
RECOMMENDATIONS FOR USE
* IGF-1 LR3 is most commonly injected once per day, 7 days per week.
* The effective dosing range is typically between 50-150 mcg per day, although a small percentage of users will elect to exceed this dosage. We do not yet know the dosing limit at which LR3 ceases to exert additional effects.
* Desensitization seems to occur after about 4 weeks of chronic usage, at which point the individual has the option of either discontinuing the peptide for a 2-4 week period (after which the individual can resume use), or the individual can elect to increase the dosage further, in order to over-ride the desensitization and continue experiencing its benefits. However, the process of desensitization will continue to occur at each ascending dosage.
MGF & PEG MGF
MGF & PEG MGF, also known as Mechano Growth Factor (or IGF-1 1Ec), is a locally expressed (within muscle tissue) splice variant of IGF-1. It is produced in response to muscular trauma/damage (training) and initiates the growth & recovery process. The 1st iso-form to be produced in response to training is known as IGF-1Ec (MGF) and it is easily the more potent of the two. This variant will continue to be produced for about 2 hours post-workout. After production of the 1st variant has ceased, production of the 2nd will begin. This 2nd iso-form will continue to be produced for roughly 24 hours, completing this initial step of the recovery-growth process.
MGF plays a significant role in muscle hyperplasia. More specifically, MGF acts as a cell proliferator, ordering the production of new stem cells in muscle tissue. These stems cells, after being exposed to the actions of IGF-1 (differentiation), will become muscle cells. However, standard MGF has a very brief active life within muscle tissue, necessitating a frequent injection schedule if one wishes to maintain active levels of the compound for even minimal periods of time. This dilemma led to the creation of a much longer lasting form of MGF called PEG MGF, or Pegylated Mechano Growth Factor. PEG MGF is a form of MGF that has been molecularly altered in order to substantially increase the compound's active life within muscle tissue. This pegylation process does not change the effects of the MGF molecule itself, but only extends the life of the compound.
MGF's short lifespan is also problematic in that the molecule will become inactive prior to entering circulation. In other words, MGF is completely absent of systematic benefits, affecting only the injected muscle. With PEG-MGF, not only does it directly affect the injected muscle to a much greater degree than standard MGF, but it's extremely long active life will allow the molecule to enter circulation and positively affect one's entire musculature.
BENEFITS OF MGF & PEG MGF
* Site Enhancement; Increased muscle/bone growth of the treated area (with added systematic effects when using the PEG version)
* Increased muscle fullness and expedited recovery of the treated area (with added systematic effects when using the PEG version)
* The ability to cause muscle cell hyperplasia of the treated area (with added systematic effects when using the PEG version) and stimulating osteoblasts
* Causes immature muscle cell nuclei to turn into fully functioning muscle fibers at the treated area (with added systematic effects when using the PEG version)
RECOMMENDATIONS FOR USE
* Since MGF is used primarily as a proliferator, it makes sense to apply this hormone in a manner which allows it to properly perform its function. If PEG-MGF is used alone, it can be administered 2-3 days per week, at a dosage of between 200-1,000 mcg per day.
* If PEG-MGF is used in conjunction with IGF-1 (which produces the best results), then the following method of administration has proven to be highly effective. Keep in mind that in order to obtain one's best results with the following program, a large number of weekly injects will be required. This protocol will demand the utmost in terms of dedication and commitment. For those who desire to follow this program, but are unwilling to endure the suggested number of weekly injects, these individuals could reduce their total injection volume by about 50-75% and still experience significant results.
The following short article not only explains how to properly implement this protocol for muscle/height/frame maxxing but it also delves into the reasoning behind the program set-up. Some of this information may be repetitive (being previously stated above), although I felt that a fluid and comprehensive explanation, as it relates solely to this program, would be particularly beneficial for potential users.
THE PROGRAM FOR MAXIMUM GROWTH
Proliferation and Differentiation. What do these two words mean, how do these processes promote muscle and height growth, and how do we optimize them through the use of PEG-MGF and IGF-1? Please allow me to break this down into its most simple form. MGF is the hormone responsible for expanding our pool of stem cells. The expansion of these cells is what's known as proliferation. Proliferation is the 1st step in the process of forming new cells. Once these stems cells have received the message to proliferate through the actions of MGF, what type of cells they become, whether muscle or otherwise, depends on the message they later receive from other hormones.
IGF-1 is what's known as a differentiator. Differentiation is the process responsible for turning immature stem cells into a defined cell type. When a stem cell is exposed to the actions of IGF-1, the cell type created is a muscle cell. However, it is very important to note that each of these processes must take place at the correct time. If one process is begun before the other has finished its work, either the entire process is short-circuited, or partial results are achieved. When a muscle or bone is exposed to stress (such as weight training), its first response is to produce localized MGF. MGF is produced only in the muscle, not in the liver like GH mediated IGF-1 production. After training, It is vital that MGF be allowed to fully perform its function of proliferation before IGF-1 is introduced into the system. Otherwise, the inhibitory actions IGF1 will immediately halt the proliferation process and reduce the total number of stem cells available for differentiation into muscle cells. In other words, introducing IGF-1 at the wrong time will limit our rate of muscle growth.
In the past, the typical manner of administering PEG MGF and IGF-1 would be to use 200-300 mg of PEG-MGF immediately post-workout 2X weekly, followed by an injection of IGF-1 the other 5 days per week. In principle this theory is sound, as the PEG-MGF will expand the number of available stem cells, which can then subsequently be differentiated by IGF-1 the following day. However, there are 3 significant problems with this method of use. For one, since PEG-MGF is typically injected only 2 X per week, the Heightmaxxer and/or gymcel is usually going to choose to inject it after training the body parts he most wants to improve, but what happens if he also trains a body part on the days he administers IGF-1? Being that IGF-1 is typically administered on the days PEG-MGF isn't (which is usually 5 days per week), it is highly likely that he is going to be training on at least some of the days he administers IGF-1. That means that on those days, the growth process involving these growth factors will be short-circuited, due to the inhibitory actions of exogenous IGF-1, and the end result will be less than optimal muscle and height/frame growth.
The second issue which arises due to the current pattern of use is that by using PEG-MGF on non-consecutive days 2X per week, the proliferation process will always be cut short due to the constant interloping of exogenous IGF-1. Because of this, the number of available stem cell will never grow very large and the potential for differentiation will remain limited. The 3rd issue is in regards to PEG-MGF dosing….it is too light. It is now proposed that using 2 mg per week is much closer to the ideal dosage than the commonly prescribed 400 mg per week. If we use prior research as a gauge for determining proper dosing, it would point to our current dosing guidelines as being inadequate. It is a certainty that higher dosages of PEG-MGF are necessary in order to maximize stem cell proliferation. Although user experiences in this dosing range are currently minimal, what has been witnessed does appear to confirm this. In addition, the proposal is scientifically sound.
Now that I have explained the logic for why the older methods of administration are believed to be flawed in their approach, I will go over how to implement the new method of administration. The PEG-MGF molecule is always used over standard MGF, as MGF has a very short active life, being only minutes in length, while PEG-MGF will stay active for days. This enables the PEG version to deliver a much more pronounced effect. It is also important to remember that the PEG attachment does not alter the effects of the MGF molecule. The PEG attachment acts purely to extend its duration of action. As for what form of IGF-1 should be chosen, I believe IGF-1 LR3 is the superior choice only because of its greatly extended active life, which is about 24 hours in length. DES IGF-1 is a very potent form of IGF-1, being about 4X as potent as IGF-1 LR3 on a mcg basis, but its active life is only about 20 minutes. So, unless one was willing and able to administer DES many times per day, LR3 remains the better option for whole-body growth. DES is superior for site enhancement and will also deliver systematic benefits, but when it comes to a single daily injection, DES cannot trump LR3 when it comes to its whole-body benefits.
In contrast to most other injectable drugs, PEG-MGF cannot be administered with a singular inject. Several micro-injects must be used because even though PEG-MGF is systematic in its effects, the injected muscle will still receive a greater amount of benefit. Why? While both steroid esters and the PEG attachment serve primarily to extend the active life of the steroid, there are critical differences between the two. With esterfied AAS, the ester must first be cleaved from the steroid before it is able to attach to the AR and cause muscle/bone growth. This is why esterfied steroids do not cause site growth (although some users think they do due to the inflammation and subsequent swelling which occurs), as the steroid will already have entered circulation and become systematic prior to the ester being cleaved from the steroid molecule. However, unlike AAS, the PEG portion of the drug does not need to be cleaved off before it is able to attach to its receptor site and deliver its message. Also unlike AAS, the MGF molecule (whether it is MGF or PEG-MGF) communicates through cell to cell interaction. Once the PEG-MGF comes in contact with a muscle cell (such as during an injection), the affected muscle cell will relay the same signal to the adjoining muscle cells. More so, this signal will eventually stop being passed along to adjoining cells, making a single inject unsuitable for treating the entire muscle.
Another characteristic of PEG-MGF, which plays a role in the way it is administered, is the fact that it causes a disproportionate degree of muscle/bone growth in the injected site, compared to the rest of the body. However, with PEG-MGF being systematic in nature, one might ask why this happens, being that the compound will eventually spread around to the entire body anyway. This is a question I would have to research, so I cannot answer it right now. Still, I speculate that there may be 3 reasons for this. For one, the injected muscle is directly exposed to the entire amount of the drug on a first come basis. Two, the compound will immediately begin attaching to receptor sites as soon as it is injected, likely using up a substantial portion of the drug before it has a chance to become systematic. Three, due to the micro-injection technique, which is explained below, the entire muscle is exposed to the actions of the drug in large quantities.
Below I will lay out the micro-injection technique. It is a pain in the ass to be sure, but due to the use of 30-31gauge insulin needles, this process is made much more tolerable. The micro-injection process involves injecting a small portion of the drug into multiple locations within the same muscle. In the case of smaller body parts, this can be as many as 14-16 injections, split bi-laterally. In larger body parts, 20 injections split bilaterally is more appropriate. Remember, MGF communicates its actions cell to cell, so this micro-injection technique must be incorporated into one's protocol if optimal results are desired. Using a small amount of injections will drastically limit the amount of muscle cells which are exposed to the actions of the MGF and a single injection will severely limit the drug's ability to turn on stem cell proliferation. Now, before anyone is turned away by the sheer volume of injections, it should be noted that this only needs to be performed twice weekly. In addition, the use of a 30-31gauge 1/2 inch insulin pin reduces scar tissue build-up to less than what would be experienced with just a couple injections using a 22 g. needle. The pain factor is almost a non-issue, as it should be near painless. Lastly, this only needs to be performed for 4 weeks, after which point MGF injections cease and are then followed by a single sub-q IGF-1 LR3 injection per day for the next 4 weeks. It is up to the individual if they want to repeat the program after its completion.
HENCE, THE CYCLE
Here is an example of how one might target their frame with this program, while height growth happens simultaneously.
Weeks 1-4
Day #1 (post-workout): Inject 1 mg of PEG-MGF into the delts/lats/side chest. Split this 1 mg up into twenty 50 mcg injections and place 10 injects on lateral deltoid, followed by 10 injects in the side of the chest near the shoulder. Make sure each injection is placed fairly evenly apart. Use a 30-31gauge 1/2 inch syringe.
Day #2 (about 3-4 days after day 1): Same as above, but donate 5 of the chest injections to the lat.
Weeks 5-8
Days 1-28: IGF-1 LR3 @ 100 mcg once daily.
Weeks 1-8
USE ANDROGENS/ANABOLICS( Test Injections, Exemestane (Aromasin), DHT Gels/Derivatives)
CONCLUSION
ITS NOT OVER YET. YOU WILL GROW LIKE A FUNGUS. (Only applies if your plates are open).
A GUIDE BY SkullDynamicsITS NOT OVER YET. YOU WILL GROW LIKE A FUNGUS. (Only applies if your plates are open).
