[Blackpill] [Spergentific Paper] Truth about Nicotine and its effects on the body

NickGurr

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Nicotine binds to the Nicotinic Acetylcholine receptors, and acts as as an agonist and also binds to the Muscarinic Acetylcholine receptors, acting as a weak antagonist.


Most of the Nicotinic Acetycholine receptors are located presynaptically, which means they control the release of neurotransmitters, while less of them are located postsynaptically, reacting to the neurotransmitters received.

Nicotine affects both of these. The Nicotinic Acetylcholine presynaptic receptors regulate the release of Acetylcholine, Dopamine, Serotonin, Glutamate, GABA and Adrenaline. Stimulation of these by Nicotine causes an increased release of the previously mentioned neurotransmitters, as well as an increased secretion of Growth Hormone. It also causes an improvement in long-term memory.

Unfortunately, prolongue exposure to Nicotine causes an increase to tolerance to its effects. Over time, as each of the neurotransmitters will stop being affected by Nicotine, the first of which is GABA. GABA regulates the release of Dopamine, so the lowered level of GABA will cause even more Dopamine to be released by Nicotine.

This tolerance can possibly be reversed by a Nicotinic Acetylcholine receptor Positive Allosteric Modulator like PNU-120596 or AVL-3288.

The GABA levels are also lowered by Nicotine’s ability to release Beta-Endorphin, which binds to the Mu Opioid receptors, which causes pain reduction, sedation, nausea, euphoria, etc.

The agonism of the Nicotinic Acetycholine receptors also cause a two-fold increase of cAMP in the muscles, which increases muscle protein catabolism, which will increase muscle loss and has the role of using muscle as an energy source. This effect is antagonized by the release of Beta-Endorphin.


Nicotine’s weak antagonism of Muscarinic Acetylcholine receptors seem to have a slight synergistic effect with the Nicotinic Acetylcholine receptor agonism, with only a few possible side effects (Contraction of the soft muscles which causes a slight urinary retention, as well as a reduced instestinal motility which can cause nausea, reduced acid secretions in the stomach).


The overall effects of Nicotine seem to be able to improve symptoms of RLS and Parkinson’s, as well as Altzheimer’s and others, with few side effects.
 

Madness

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I don’t really vape anymore since I’m afraid it will stunt my growth. Jfl teachers are so dumb the last time I juuled was right in front of my teacher and she believed I didn’t since I held the smoke in
 

NickGurr

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I don’t really vape anymore since I’m afraid it will stunt my growth. Jfl teachers are so dumb the last time I juuled was right in front of my teacher and she believed I didn’t since I held the smoke in
I cant tell if youre being serious on the second part, but Nicotine increases growth hormone levels
 

AyWiz

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Didn’t read too much high iq, so what’s the point ?electronic cigarette is bad or good ?
 

Afrikancel

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Nicotine binds to the Nicotinic Acetylcholine receptors, and acts as as an agonist and also binds to the Muscarinic Acetylcholine receptors, acting as a weak antagonist.


Most of the Nicotinic Acetycholine receptors are located presynaptically, which means they control the release of neurotransmitters, while less of them are located postsynaptically, reacting to the neurotransmitters received.

Nicotine affects both of these. The Nicotinic Acetylcholine presynaptic receptors regulate the release of Acetylcholine, Dopamine, Serotonin, Glutamate, GABA and Adrenaline. Stimulation of these by Nicotine causes an increased release of the previously mentioned neurotransmitters, as well as an increased secretion of Growth Hormone. It also causes an improvement in long-term memory.

Unfortunately, prolongue exposure to Nicotine causes an increase to tolerance to its effects. Over time, as each of the neurotransmitters will stop being affected by Nicotine, the first of which is GABA. GABA regulates the release of Dopamine, so the lowered level of GABA will cause even more Dopamine to be released by Nicotine.

This tolerance can possibly be reversed by a Nicotinic Acetylcholine receptor Positive Allosteric Modulator like PNU-120596 or AVL-3288.

The GABA levels are also lowered by Nicotine’s ability to release Beta-Endorphin, which binds to the Mu Opioid receptors, which causes pain reduction, sedation, nausea, euphoria, etc.

The agonism of the Nicotinic Acetycholine receptors also cause a two-fold increase of cAMP in the muscles, which increases muscle protein catabolism, which will increase muscle loss and has the role of using muscle as an energy source. This effect is antagonized by the release of Beta-Endorphin.


Nicotine’s weak antagonism of Muscarinic Acetylcholine receptors seem to have a slight synergistic effect with the Nicotinic Acetylcholine receptor agonism, with only a few possible side effects (Contraction of the soft muscles which causes a slight urinary retention, as well as a reduced instestinal motility which can cause nausea, reduced acid secretions in the stomach).


The overall effects of Nicotine seem to be able to improve symptoms of RLS and Parkinson’s, as well as Altzheimer’s and others, with few side effects.
I acually understand this and am familiar with GABA and the role of nicotine. This is correct science. Well written peice. @Weed @11gaijin sticky this
 
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Madness

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I cant tell if youre being serious on the second part, but Nicotine increases growth hormone levels
Yes I’m being serious. So I can juul and vape as hard as I want and I might even grow taller. Tbh most people here probably can’t even handle high nic (50 nic salts)
 

NickGurr

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Yes I’m being serious. So I can juul and vape as hard as I want and I might even grow taller. Tbh most people here probably can’t even handle high nic (50 nic salts)
I go trough like 5 cigarettes in a day tbh, will probably switch to vaping soon and maybe ween off

And yes, it does raise GH from my research (you can see it in the main post. i used some gay spergentific words but i tried to explain most of it too), but you dont need to get 100 buzzes a day for the positive effects
 

IntolerantSocialist

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I'm planning to die anyways so who cares?
 

mido the slayer

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Smoking is bad kid
 

IntolerantSocialist

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Madness

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I go trough like 5 cigarettes in a day tbh, will probably switch to vaping soon and maybe ween off

And yes, it does raise GH from my research (you can see it in the main post. i used some gay spergentific words but i tried to explain most of it too), but you dont need to get 100 buzzes a day for the positive effects
Smoking is proven to stunt longitudinal skeletal growth however there is not much of a connection to nicotine on its own. However in addition to raising gh it raises cortisol and prolactin. So you should also take a ai if you plan on taking nicotine for whatever reason. Overall it won’t effect your height much
 

NickGurr

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Smoking is proven to stunt longitudinal skeletal growth however there is not much of a connection to nicotine on its own. However in addition to raising gh it raises cortisol and prolactin. So you should also take a ai if you plan on taking nicotine for whatever reason. Overall it won’t effect your height much
A single i.v. injection of nicotine resulted in desensitization of the prolactin response to a subsequent injection of nicotine given 1 to 2 hr later.
Says the study I just looked up. Tbh it might, the way Nicotine works is really complicated. I will look it up
 

Madness

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Says the study I just looked up. Tbh it might, the way Nicotine works is really complicated. I will look it up
It was “nicotine” from smoking so I’m assuming the dumb cunts fucked up and measured from other factors also. I had trouble finding any studies on vaping though. A nic injection is different too vaping since vape juices have other chemicals.
 

NickGurr

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You can only become subhuman after 18 theory confirmed. Also, stop derailing the thread you stupid cunt, go shitpost somewhere else
It was “nicotine” from smoking so I’m assuming the dumb cunts fucked up and measured from other factors also. I had trouble finding any studies on vaping though. A nic injection is different too vaping since vape juices have other chemicals.
Vape juices contain PG and VG which have no effect at all. Also, after inhalation almost all of it goes directly into the bloodstream so it's the same as an IV injection tbh
 

Madness

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Hey nigga I came here at 13. I found it from going on incels.me as a bluepilled kid to lurk when I saw a banner saying new looksmax site, so I went and saw the people seemed nicer here (nibba intel and ethnik). The rest is history


Give the kid a break me and him will ascend.
You can only become subhuman after 18 theory confirmed. Also, stop derailing the thread you stupid cunt, go shitpost somewhere else

Vape juices contain PG and VG which have no effect at all. Also, after inhalation almost all of it goes directly into the bloodstream so it's the same as an IV injection tbh
Yeah but gay Chinese niggas also shove in other shit
 

mido the slayer

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Hey nigga I came here at 13. I found it from going on incels.me as a bluepilled kid to lurk when I saw a banner saying new looksmax site, so I went and saw the people seemed nicer here (nibba intel and ethnik). The rest is history


Give the kid a break me and him will ascend.
Look at him he started attacking me for no reason
 

NickGurr

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Yeah but gay Chinese niggas also shove in other shit
Then make your own, although there's nothing they can really put it that would make sense. Or chew the nicotine gum, it gets absorbed pretty well

EDIT: Also, Dopamine supresses Prolactin, and dopamine gets released by Nicotine

EDIT 2: Also, Chollinergic drugs inhibit Somatostatin (GH inibitor), besides the other ways they increase GH
 
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JellyBelly

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Oh sorry it’s cuz i’m french and try to be belingual haha my friend
Hate me,jealous me and return fap on gay furry porn
the eternal frenchman
 

JellyBelly

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The Dude Abides

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Thanks for the based thread :feelsokman:

Let us spread the nicotine pill brother.
I thought nicotin was cancerous but after being hounded with ads telling me smoking was anada shoah I'm curious as to why it's so heavily attacked I DONT EVEN SMOKE STOP TELLING ME TO STOP :feelsree:
 
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I thought nicotin was cancerous but after being hounded with ads telling me smoking was anada shoah I'm curious as to why it's so heavily attacked I DONT EVEN SMOKE STOP TELLING ME TO STOP :feelsree:
Nicotine is not the same as tobacco tbh.

Cigarettes are very well cancerous. Especially the additives and the shit ingredients.
Which makes me think that high quality organic tobacco is way less dangerous than the cancer cigs sold.
 

The Dude Abides

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Nicotine is not the same as tobacco tbh.

Cigarettes are very well cancerous. Especially the additives and the shit ingredients.
Which makes me think that high quality organic tobacco is way less dangerous than the cancer cigs sold.
it'd be cool if rolling our own cigs turns out to be healthy
 
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it'd be cool if rolling our own cigs turns out to be healthy
There is still smoke particles and carbon monoxide so it will be non-healthy in that regard.
It will be very cool if society started seeing both sides srs.
 

The Dude Abides

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There is still smoke particles and carbon monoxide so it will be non-healthy in that regard.
It will be very cool if society started seeing both sides srs.
Its all just too much:feelsrope:
 

NickGurr

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Its all just too much:feelsrope:
Just use a vape. I ordered one for myself to get off cigs and to keep me from going into a psychotic sperg episode

It will be very cool if society started seeing both sides srs.
JFL fuck them, they can keep getting their info from mom blogs, we will sit on our big boy thrones vaping and laughing at them :feelshaha:
 

The Dude Abides

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Just use a vape. I ordered one for myself to get off cigs and to keep me from going into a psychotic sperg episode


JFL fuck them, they can keep getting their info from mom blogs, we will sit on our big boy thrones vaping and laughing at them :feelshaha:
i dont want to start
tbh tbh
 

NickGurr

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Relating to cortisol: For new smokers who have not yet build a GABA tolerance, the cortisol release will be partially suppressed by GABA (I think), but for more advanced smokers, they might get a cortisol release due to the adrenaline. Idk how big the effect is tho, will look into it

from cigs? cage
no, without them, it's why I started smokin

i dont want to start
tbh tbh
low t tbh
 

NickGurr

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It is the reason I want to get on them lmao
They're legit, especially after you do it for a while. Also PKC inhibition has been shown to reduce bipolar disorder and if vit C is a PKC inhibitor, then you can take it (didnt look into it myself)

I recommend you go with a vape though, it's more versatile and is way more healthy. Or gums
 
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They're legit, especially after you do it for a while. Also PKC inhibition has been shown to reduce bipolar disorder and if vit C is a PKC inhibitor, then you can take it (didnt look into it myself)
It failed trials tho srs.
1 high quality strong cigar per day for schizo is legit
 

NickGurr

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It failed trials tho srs.
1 high quality strong cigar per day for schizo is legit
what failed trials

and yeh you can go with cigars too, health is a meme anyway, the jews poison us daily
Nicotine is the chad smoking drug tbh ngl.


Weed is legit low t high e.
Chad juuls after fucking stacy while incels smoke weed and LDAR
 

JellyBelly

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Nicotine gum and patches are also good when you gotta do your ‘job’ for 12 hours and have to be there 110%.
I don’t like nicotine gum tho, takes too long, caffeine gum + nico patches is the best combo imo.
 

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