[Blackpill] [Spergentific Paper] Truth about Nicotine and its effects on the body

NickGurr

NickGurr

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Nicotine binds to the Nicotinic Acetylcholine receptors, and acts as as an agonist and also binds to the Muscarinic Acetylcholine receptors, acting as a weak antagonist.


Most of the Nicotinic Acetycholine receptors are located presynaptically, which means they control the release of neurotransmitters, while less of them are located postsynaptically, reacting to the neurotransmitters received.

Nicotine affects both of these. The Nicotinic Acetylcholine presynaptic receptors regulate the release of Acetylcholine, Dopamine, Serotonin, Glutamate, GABA and Adrenaline. Stimulation of these by Nicotine causes an increased release of the previously mentioned neurotransmitters, as well as an increased secretion of Growth Hormone. It also causes an improvement in long-term memory.

Unfortunately, prolongue exposure to Nicotine causes an increase to tolerance to its effects. Over time, as each of the neurotransmitters will stop being affected by Nicotine, the first of which is GABA. GABA regulates the release of Dopamine, so the lowered level of GABA will cause even more Dopamine to be released by Nicotine.

This tolerance can possibly be reversed by a Nicotinic Acetylcholine receptor Positive Allosteric Modulator like PNU-120596 or AVL-3288.

The GABA levels are also lowered by Nicotine’s ability to release Beta-Endorphin, which binds to the Mu Opioid receptors, which causes pain reduction, sedation, nausea, euphoria, etc.

The agonism of the Nicotinic Acetycholine receptors also cause a two-fold increase of cAMP in the muscles, which increases muscle protein catabolism, which will increase muscle loss and has the role of using muscle as an energy source. This effect is antagonized by the release of Beta-Endorphin.


Nicotine’s weak antagonism of Muscarinic Acetylcholine receptors seem to have a slight synergistic effect with the Nicotinic Acetylcholine receptor agonism, with only a few possible side effects (Contraction of the soft muscles which causes a slight urinary retention, as well as a reduced instestinal motility which can cause nausea, reduced acid secretions in the stomach).


The overall effects of Nicotine seem to be able to improve symptoms of RLS and Parkinson’s, as well as Altzheimer’s and others, with few side effects.
 
ZyzzReincarnate

ZyzzReincarnate

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juuls me
 
Madness

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I don’t really vape anymore since I’m afraid it will stunt my growth. Jfl teachers are so dumb the last time I juuled was right in front of my teacher and she believed I didn’t since I held the smoke in
 
NickGurr

NickGurr

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I don’t really vape anymore since I’m afraid it will stunt my growth. Jfl teachers are so dumb the last time I juuled was right in front of my teacher and she believed I didn’t since I held the smoke in
I cant tell if youre being serious on the second part, but Nicotine increases growth hormone levels
 
AyWiz

AyWiz

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Didn’t read too much high iq, so what’s the point ?electronic cigarette is bad or good ?
 
Afrikancel

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Nicotine binds to the Nicotinic Acetylcholine receptors, and acts as as an agonist and also binds to the Muscarinic Acetylcholine receptors, acting as a weak antagonist.


Most of the Nicotinic Acetycholine receptors are located presynaptically, which means they control the release of neurotransmitters, while less of them are located postsynaptically, reacting to the neurotransmitters received.

Nicotine affects both of these. The Nicotinic Acetylcholine presynaptic receptors regulate the release of Acetylcholine, Dopamine, Serotonin, Glutamate, GABA and Adrenaline. Stimulation of these by Nicotine causes an increased release of the previously mentioned neurotransmitters, as well as an increased secretion of Growth Hormone. It also causes an improvement in long-term memory.

Unfortunately, prolongue exposure to Nicotine causes an increase to tolerance to its effects. Over time, as each of the neurotransmitters will stop being affected by Nicotine, the first of which is GABA. GABA regulates the release of Dopamine, so the lowered level of GABA will cause even more Dopamine to be released by Nicotine.

This tolerance can possibly be reversed by a Nicotinic Acetylcholine receptor Positive Allosteric Modulator like PNU-120596 or AVL-3288.

The GABA levels are also lowered by Nicotine’s ability to release Beta-Endorphin, which binds to the Mu Opioid receptors, which causes pain reduction, sedation, nausea, euphoria, etc.

The agonism of the Nicotinic Acetycholine receptors also cause a two-fold increase of cAMP in the muscles, which increases muscle protein catabolism, which will increase muscle loss and has the role of using muscle as an energy source. This effect is antagonized by the release of Beta-Endorphin.


Nicotine’s weak antagonism of Muscarinic Acetylcholine receptors seem to have a slight synergistic effect with the Nicotinic Acetylcholine receptor agonism, with only a few possible side effects (Contraction of the soft muscles which causes a slight urinary retention, as well as a reduced instestinal motility which can cause nausea, reduced acid secretions in the stomach).


The overall effects of Nicotine seem to be able to improve symptoms of RLS and Parkinson’s, as well as Altzheimer’s and others, with few side effects.
I acually understand this and am familiar with GABA and the role of nicotine. This is correct science. Well written peice. @Weed @11gaijin sticky this
 
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Madness

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I cant tell if youre being serious on the second part, but Nicotine increases growth hormone levels
Yes I’m being serious. So I can juul and vape as hard as I want and I might even grow taller. Tbh most people here probably can’t even handle high nic (50 nic salts)
 
NickGurr

NickGurr

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Yes I’m being serious. So I can juul and vape as hard as I want and I might even grow taller. Tbh most people here probably can’t even handle high nic (50 nic salts)
I go trough like 5 cigarettes in a day tbh, will probably switch to vaping soon and maybe ween off

And yes, it does raise GH from my research (you can see it in the main post. i used some gay spergentific words but i tried to explain most of it too), but you dont need to get 100 buzzes a day for the positive effects
 
IntolerantSocialist

IntolerantSocialist

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I'm planning to die anyways so who cares?
 
mido the slayer

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Smoking is bad kid
 
IntolerantSocialist

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Madness

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I go trough like 5 cigarettes in a day tbh, will probably switch to vaping soon and maybe ween off

And yes, it does raise GH from my research (you can see it in the main post. i used some gay spergentific words but i tried to explain most of it too), but you dont need to get 100 buzzes a day for the positive effects
Smoking is proven to stunt longitudinal skeletal growth however there is not much of a connection to nicotine on its own. However in addition to raising gh it raises cortisol and prolactin. So you should also take a ai if you plan on taking nicotine for whatever reason. Overall it won’t effect your height much
 
Madness

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NickGurr

NickGurr

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Smoking is proven to stunt longitudinal skeletal growth however there is not much of a connection to nicotine on its own. However in addition to raising gh it raises cortisol and prolactin. So you should also take a ai if you plan on taking nicotine for whatever reason. Overall it won’t effect your height much
A single i.v. injection of nicotine resulted in desensitization of the prolactin response to a subsequent injection of nicotine given 1 to 2 hr later.
Says the study I just looked up. Tbh it might, the way Nicotine works is really complicated. I will look it up
 
NickGurr

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Oh sorry it’s cuz i’m french and to be belingual haha my friend
Hate me,jealous me and return fap on gay furry porn
belinguals me
 
mido the slayer

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Oh sorry it’s cuz i’m french and try to be belingual haha my friend
Hate me,jealous me and return fap on gay furry porn
Imagine being 14 years old incel
39973

39975
 
Madness

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Says the study I just looked up. Tbh it might, the way Nicotine works is really complicated. I will look it up
It was “nicotine” from smoking so I’m assuming the dumb cunts fucked up and measured from other factors also. I had trouble finding any studies on vaping though. A nic injection is different too vaping since vape juices have other chemicals.
 
NickGurr

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You can only become subhuman after 18 theory confirmed. Also, stop derailing the thread you stupid cunt, go shitpost somewhere else
It was “nicotine” from smoking so I’m assuming the dumb cunts fucked up and measured from other factors also. I had trouble finding any studies on vaping though. A nic injection is different too vaping since vape juices have other chemicals.
Vape juices contain PG and VG which have no effect at all. Also, after inhalation almost all of it goes directly into the bloodstream so it's the same as an IV injection tbh
 
Madness

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Hey nigga I came here at 13. I found it from going on incels.me as a bluepilled kid to lurk when I saw a banner saying new looksmax site, so I went and saw the people seemed nicer here (nibba intel and ethnik). The rest is history


Give the kid a break me and him will ascend.
You can only become subhuman after 18 theory confirmed. Also, stop derailing the thread you stupid cunt, go shitpost somewhere else

Vape juices contain PG and VG which have no effect at all. Also, after inhalation almost all of it goes directly into the bloodstream so it's the same as an IV injection tbh
Yeah but gay Chinese niggas also shove in other shit
 
mido the slayer

mido the slayer

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Hey nigga I came here at 13. I found it from going on incels.me as a bluepilled kid to lurk when I saw a banner saying new looksmax site, so I went and saw the people seemed nicer here (nibba intel and ethnik). The rest is history


Give the kid a break me and him will ascend.
Look at him he started attacking me for no reason
 

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