Is minoxidil an anti androgen(aspie scientists gtfih )

[HighTierNormie]

I'm currently 18 and dont want to take any anti-androgens and stunt my development but have been using Minox on my face for the past 2 months to get a thicker beard but I found a study posted by @Lifeisgood72 claiming Minox to possibly suppress androgen receptors as its method of action https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039155/
honestly, all the Minox theories are really confusing some people say its a vasodilator, some people say it grows hair by reducing collagen and now apparently it works by blocking androgens.
if this is the case then I'm gonna get off the stuff until I'm 22 but could someone pls explain this shit to me

 

[6'4 looksmaxxxer]

Short answer is no. Minox is a vasodilatator and encourages hair growth by increasing blood flow and oxygenation to hair follicules. Virtually it has 0 effect on hormonal profile. Clinical studies suspect though that it may lower collagen in some individuals.

 

[HighTierNormie]

Short answer is no. Minox is a vasodilatator and encourages hair growth by increasing blood flow and oxygenation to hair follicules. Virtually it has 0 effect on hormonal profile. Clinical studies suspect though that it may lower collagen in some individuals.

yh but look at the study
To further clarify whether minoxidil suppresses human AR target gene transcription, we co-transfected PC-3 cells with PSG5-AR and a PSA-Luc reporter construct containing 1.5 kb of the prostate-specific antigen (PSA) promoter linked to the luciferase gene. As shown in Fig. Fig.1B,1B, minoxidil suppressed AR transcriptional activity in this PSA-Luc reporter assay. Furthermore, as shown in Fig. Fig.1C1C (PSA, lanes 3 and 4 vs. lane 2), this phenomenon translated into a decrease in PSA protein level after treatment with minoxidil for 72 h. These data further support the conclusion that minoxidil is capable of suppressing AR-related functions.

Clinically, anti-androgens are used to treat prostate cancer. To further test minoxidil suppression of AR-related function, we tested the effects of minoxidil on the growth of LNCaP cells, an androgen-sensitive prostate cancer cell line that, as noted above, endogenously expresses AR. As shown in Fig. Fig.1D,1D, minoxidil suppressed DHT-dependent LNCaP cell growth in concentration-dependent manner. Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth.
minoxidil is literally working like finasteride
jfl i've made a mistake doing this shit fuck me AHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

 

[6'4 looksmaxxxer]

yh but look at the study
To further clarify whether minoxidil suppresses human AR target gene transcription, we co-transfected PC-3 cells with PSG5-AR and a PSA-Luc reporter construct containing 1.5 kb of the prostate-specific antigen (PSA) promoter linked to the luciferase gene. As shown in Fig. Fig.1B,1B, minoxidil suppressed AR transcriptional activity in this PSA-Luc reporter assay. Furthermore, as shown in Fig. Fig.1C1C (PSA, lanes 3 and 4 vs. lane 2), this phenomenon translated into a decrease in PSA protein level after treatment with minoxidil for 72 h. These data further support the conclusion that minoxidil is capable of suppressing AR-related functions.

Clinically, anti-androgens are used to treat prostate cancer. To further test minoxidil suppression of AR-related function, we tested the effects of minoxidil on the growth of LNCaP cells, an androgen-sensitive prostate cancer cell line that, as noted above, endogenously expresses AR. As shown in Fig. Fig.1D,1D, minoxidil suppressed DHT-dependent LNCaP cell growth in concentration-dependent manner. Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth.
minoxidil is literally working like finasteride
jfl i've made a mistake doing this shit fuck me AHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

The suppression is so miniscule though it doesn't matter

 

[HighTierNormie]

The suppression is so miniscule though it doesn't matter

its says that at the highest concentration that DHT was no longer present, honestly i wouldn't mind blocking DHT once im atleast 25 so then my development is complete, i acc plan to get on finasteride if there is no better alternative but i can't be using this shit now and stunting my body

 

[6'4 looksmaxxxer]

its says that at the highest concentration that DHT was no longer present, honestly i wouldn't mind blocking DHT once im atleast 25 so then my development is complete, i acc plan to get on finasteride if there is no better alternative but i can't be using this shit now and stunting my body

It might reduce dht a lot if you abuse the shit out of it and especially when you take it orally but i really doubt that local minox use with the recommended dose would impact dht production in any serious manner

 

[HighTierNormie]

there were people on hair loss forums claiming minox gave them ED and i was laughing my ass off...

 

[6'4 looksmaxxxer]

there were people on hair loss forums claiming minox gave them ED and i was laughing my ass off...

Lol low iq autists it doesn't i used it and i am fine

 

[HighTierNormie]

It might reduce dht a lot if you abuse the shit out of it and especially when you take it orally but i really doubt that local minox use with the recommended dose would impact dht production in any impactful manner

i'll be honest i used to use like 2 ml a day which is twice the normal dose for past 3 months so my dicks probably already stunted
acc when i think about it doesnt make sense, ppl use minox to grow facial hair and that requires DHT to grow so minox cant be blocking it out?

 

[6'4 looksmaxxxer]

i'll be honest i used to use like 2 ml a day which is twice the normal dose for past 3 months so my dicks probably already stunted

Jfl i assure u there's no correlation or whatsoever but if you're so paranoid about it drop and use ketoconazole 2% shampoo every other day let it stay on your scalp 5 minutes for it to block a'drogens on the scalp then wash it off

 

[gaypharoah]

yh but look at the study
To further clarify whether minoxidil suppresses human AR target gene transcription, we co-transfected PC-3 cells with PSG5-AR and a PSA-Luc reporter construct containing 1.5 kb of the prostate-specific antigen (PSA) promoter linked to the luciferase gene. As shown in Fig. Fig.1B,1B, minoxidil suppressed AR transcriptional activity in this PSA-Luc reporter assay. Furthermore, as shown in Fig. Fig.1C1C (PSA, lanes 3 and 4 vs. lane 2), this phenomenon translated into a decrease in PSA protein level after treatment with minoxidil for 72 h. These data further support the conclusion that minoxidil is capable of suppressing AR-related functions.

Clinically, anti-androgens are used to treat prostate cancer. To further test minoxidil suppression of AR-related function, we tested the effects of minoxidil on the growth of LNCaP cells, an androgen-sensitive prostate cancer cell line that, as noted above, endogenously expresses AR. As shown in Fig. Fig.1D,1D, minoxidil suppressed DHT-dependent LNCaP cell growth in concentration-dependent manner. Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth.
minoxidil is literally working like finasteride
jfl i've made a mistake doing this shit fuck me AHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

"Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth"
Please read more carefully. The action of 5 alpha reductase which reduces DHT actually increases the production of the materials you want to reap the benefits of, whilst reducing those which harm you. Not all androgenic hormones have a positive effect.

 

[HighTierNormie]

"Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth"
Please read more carefully. The action of 5 alpha reductase which reduces DHT actually increases the production of the materials you want to reap the benefits of, whilst reducing those which harm you. Not all androgenic hormones have a positive effect.

dht is not a useless hormone it is very important especially during puberty. I dont want it blocked

 

[6'4 looksmaxxxer]

"Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth"
Please read more carefully. The action of 5 alpha reductase which reduces DHT actually increases the production of the materials you want to reap the benefits of, whilst reducing those which harm you. Not all androgenic hormones have a positive effect.

Dht is very important for men especially libido wise

 

[gaypharoah]

Dht is very important for men especially libido wise

dht is not a useless hormone it is very important especially during puberty. I dont want it blocked

My bad did not consider age at all. I'm going to read the article to better understand the figures they present though, miniscule figures wouldn't mean much.

 

[Deleted member 773]

its says that at the highest concentration that DHT was no longer present, honestly i wouldn't mind blocking DHT once im atleast 25 so then my development is complete, i acc plan to get on finasteride if there is no better alternative but i can't be using this shit now and stunting my body

I'm 16, started min when I was 15 and noticed a decrease in libido. I can still nutt and shit but I probably stunted my dick growth (good thing I'm 7 inches already)

5 months off of it, I am generally hornier now. Before I used to go 5 days without any urge to masturbate now I find myself looking at reddit porn subs again. But I still can't put on muscle as well as I used to. Collagen has also gotten slightly better but still subhuman levels. Asking a real doctor about it in a few weeks.

TLR Minoxidil DHT sides are real but not as bad as fin

 

[HighTierNormie]

I'm 16, started min when I was 15 and noticed a decrease in libido. I can still nutt and shit but I probably stunted my dick growth (good thing I'm 7 inches already)

5 months off of it, I am generally hornier now. Before I used to go 5 days without any urge to masturbate now I find myself looking at reddit porn subs again. But I still can't put on muscle as well as I used to. Collagen has also gotten slightly better but still subhuman levels. Asking a real doctor about it in a few weeks.

TLR Minoxidil DHT sides are real but not as bad as fin

bro i really cant tell if your blaming everything on minox or it really is as bad as you say it is, like this shit got me real fucking stressed

 

[gaypharoah]

After re-reading the paper it seems to have concluded these results systematically, meaning provided dosage used is not relatively high, it would not significantly affect androgen receptor function to the point of opposing hormone response due to the low ratio of percutaneous absorption (1:0.34).

 

[Deleted member 773]

bro i really cant tell if your blaming everything on minox or it really is as bad as you say it is, like this shit got me real fucking stressed

After re-reading the paper it seems to have concluded these results systematically, meaning provided dosage used is not relatively high, it would not significantly affect androgen receptor function to the point of opposing hormone response due to the low ratio of percutaneous absorption (1:0.34).

My issue was, I'm 16, used it right after dermarolling, and too much of it, for 6 MONTHS.

I didn't abuse it THAT badly but still. Not too surprising that it's taking me this long to recover from it.

 

[6'4 looksmaxxxer]

After re-reading the paper it seems to have concluded these results systematically, meaning provided dosage used is not relatively high, it would not significantly affect androgen receptor function to the point of opposing hormone response due to the low ratio of percutaneous absorption (1:0.34).

It virtually has no imapct on hormones jfl

 

[HighTierNormie]

After re-reading the paper it seems to have concluded these results systematically, meaning provided dosage used is not relatively high, it would not significantly affect androgen receptor function to the point of opposing hormone response due to the low ratio of percutaneous absorption (1:0.34).

yh good thing its only a topical, i'll keep usin at 0.5ml per day just for eyebrows than get off it in a year

My issue was, I'm 16, used it right after dermarolling, and too much of it, for 6 MONTHS.

I didn't abuse it THAT badly but still. Not too surprising that it's taking me this long to recover from it.

fuck i used to dermaroll and rub in minox once a week

 

[her]

yh good thing its only a topical, i'll keep usin at 0.5ml per day just for eyebrows than get off it in a year

you will lose your gains if you get off it

 

[gaypharoah]

yh good thing its only a topical, i'll keep usin at 0.5ml per day just for eyebrows than get off it in a year

Seems like a much safer option. I wouldn't be that afraid, especially if you implement exercise and such into your daily routine.

 

[HighTierNormie]

you will lose your gains if you get off it

i didnt make any strong gains but my eyebrows look better so i'll use it just for that

 

[gaypharoah]

i didnt make any strong gains but my eyebrows look better so i'll use it just for that

He probably meant brow gains since minoxidil is sometimes required in maintenance. This isn't the same for everyone though.

 

[HighTierNormie]

He probably meant brow gains since minoxidil is sometimes required in maintenance. This isn't the same for everyone though.

i heard that once hairs become terminal they dont need minox as long as it isnt head hair

 

[FaceandHFD]

confirmed low t if minox gives you sides

 

[gaypharoah]

i heard that once hairs become terminal they dont need minox as long as it isnt head hair

That's because you only see terminal hair growth in brow hair since there is no DHT-caused miniaturization. You will see permanent results, but those which you come to before stopping treatment are not guaranteed to be the true permanent results. In essence, you may not experience the full effect of minoxidil on brow hair permanently, but you probably will experience some sort of an effect permanently. Again this differs per individual.

 

[Stare]

"Notably, at the highest concentration, cell growth was suppressed to a level comparable to that observed in the absence of DHT. These data provide the first demonstration that minoxidil can suppress AR-related functions, including AR transcription and AR-related cell growth"
Please read more carefully. The action of 5 alpha reductase which reduces DHT actually increases the production of the materials you want to reap the benefits of, whilst reducing those which harm you. Not all androgenic hormones have a positive effect.

Wrong
5α-Reductase is the enzyme that turns testosterone into DHT, so it increases DHT. Finasteride is an inhibitor of 5α-Reductase, not letting it turn testosterone into DHT and lowering DHT slowly because of that.

 

[gaypharoah]

Wrong
5α-Reductase is the enzyme that turns testosterone into DHT, so it increases DHT. Finasteride is an inhibitor of 5α-Reductase, not letting it turn testosterone into DHT and lowering DHT slowly because of that.

You are correct. I meant to say the action of the inhibitor .

 

[LordNorwood]

Lol low iq autists it doesn't i used it and i am fine

You used it? I thought you had no hair loss?

 

[DOggo]

regardless, I'd not do it at 18. 21 at the bare minimum, 25 should be preferable.

 

[6'4 looksmaxxxer]

You used it? I thought you had no hair loss?

Only very slight temple recessions when i used heavy steroids like tren the hair came back now