AySab
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Now, IK this peptide has been mentioned before but it doesn’t have that much attention, so i’ll reintroduce it again.
As we know, acne is both caused by inflammation and bacteria which is caused by too many factors (way too much to list down) which is why things like isotretinoin + anti-histamine, topical or oral antibiotics, exfoliators are prescribed.
Now, as resistance to antibiotics grows stronger and more common, people are usually prescribed isotretinoin to help treat or cure their acne. but as we know, isotretinoin has affects on the hormones we secrete and can cause side effects which makes us think to ourselves whether we should take it or not as it seems way too risky.
now, if you’re already taking isotretinoin with a anti-histamine, then you can probably skip this whole thread or maybe just give it a read and learn something new.
Now a peptide that has insane effects on acne has been introduced as LZ1 which is a anti microbial peptide with anti-inflammatory effects has been introduced as potentially the new treatment for acne.
To give some background information before you give the study a read yourself, LZ1 is a peptide with 15 amino acid residues containing strong antimicrobial properties against bacteria pathogens of acne vulgaris including Propionibacterium acnes, Staphylococcus epidermidis and S. aureus.
The minimal inhibitory concentration against three strains of P. acnes was only 0.6 µg/ml, which is 4 times lower than that of clindamycin (a topical antibiotic).
Meaning, at 0.6µg/ml, it was able to inhibit acne which was 4 times lower dose of clindamycin, this was also the minimum dose for inhibiting acne.
LZ1 significantly reduced the number of P. acnes colonized on the ear, P. acnes-induced ear swelling, and inflammatory cell infiltration. It ameliorated inflammation induced by P. acnes by inhibiting the secretion of inflammatory factors including tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β.
Meaning, it has anti-inflammatory properties when used against acne. (Don’t know if a generic anti-histamine might be stronger).
LZ1 showed little cytotoxicity on human keratinocyte and hemolytic activity on human blood red cells. Furthermore, LZ1 was very stable in human plasma.
This means that it has great compatibility with humans and won’t induce side effects like isotretinoin can.
Combined with its potential bactericidal and anti-inflammatory properties, simple structure and high stability, LZ1 might be an ideal candidate for the treatment of acne.
This was the conclusion, what do you guys think?
It looks like it lasted longer and is stronger than LL-37, another peptide containing anti microbial properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755965/
As we know, acne is both caused by inflammation and bacteria which is caused by too many factors (way too much to list down) which is why things like isotretinoin + anti-histamine, topical or oral antibiotics, exfoliators are prescribed.
Now, as resistance to antibiotics grows stronger and more common, people are usually prescribed isotretinoin to help treat or cure their acne. but as we know, isotretinoin has affects on the hormones we secrete and can cause side effects which makes us think to ourselves whether we should take it or not as it seems way too risky.
now, if you’re already taking isotretinoin with a anti-histamine, then you can probably skip this whole thread or maybe just give it a read and learn something new.
Now a peptide that has insane effects on acne has been introduced as LZ1 which is a anti microbial peptide with anti-inflammatory effects has been introduced as potentially the new treatment for acne.
To give some background information before you give the study a read yourself, LZ1 is a peptide with 15 amino acid residues containing strong antimicrobial properties against bacteria pathogens of acne vulgaris including Propionibacterium acnes, Staphylococcus epidermidis and S. aureus.
The minimal inhibitory concentration against three strains of P. acnes was only 0.6 µg/ml, which is 4 times lower than that of clindamycin (a topical antibiotic).
Meaning, at 0.6µg/ml, it was able to inhibit acne which was 4 times lower dose of clindamycin, this was also the minimum dose for inhibiting acne.
LZ1 significantly reduced the number of P. acnes colonized on the ear, P. acnes-induced ear swelling, and inflammatory cell infiltration. It ameliorated inflammation induced by P. acnes by inhibiting the secretion of inflammatory factors including tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β.
Meaning, it has anti-inflammatory properties when used against acne. (Don’t know if a generic anti-histamine might be stronger).
LZ1 showed little cytotoxicity on human keratinocyte and hemolytic activity on human blood red cells. Furthermore, LZ1 was very stable in human plasma.
This means that it has great compatibility with humans and won’t induce side effects like isotretinoin can.
Combined with its potential bactericidal and anti-inflammatory properties, simple structure and high stability, LZ1 might be an ideal candidate for the treatment of acne.
This was the conclusion, what do you guys think?
It looks like it lasted longer and is stronger than LL-37, another peptide containing anti microbial properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755965/
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